Dr Man-Kai Wan and the medical students of the Hong Kong College of Medicine at Nethersole Hospital in 1898

Wong, TS

doi:10.12809/hkmj-hkmms202112

Hong Kong Med J 2021

DOI: 10.12809/hkmj-hkmms202112

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Dr Man-Kai Wan and the medical students of the Hong Kong College of Medicine at Nethersole Hospital in 1898

TS Wong¹

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Cited by 7 publications

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Modulation of Myb‐induced NF‐kB ‐STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors

Tian

Qiao

et al. 2019

Journal Cellular Physiology

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c-Myb regulates tumorigenesis in multiple cancers. Here we show, for the first time, the mechanism of c-Myb-mediated proliferation, invasion, and drug resistance in ovarian cancer (OC), the most lethal gynecological cancer, and a comparative analyses of dietary agents, curcumin, epigallocatechin-3-gallate (EGCG), and sulforaphane in inhibiting c-Myb activity. We evaluated myb expression in patients with OC and found its increased expression in patients with cancer, compared with normal controls and in higher grade tumors, compared with low-grade tumors. Using ES2 and OVCAR3 cell line models, along with the silencing or overexpression of c-Myb, we establish a role of c-Myb in determining resistance to cisplatin. c-Myb overexpression activated NF-κB and STAT3 signaling leading to enhanced proliferation, invasion, and cisplatin resistance. Contrary to this, silencing of c-Myb inhibited proliferation, invasion, and sensitized OC cells to cisplatin. Further, among the dietary agents tested, EGCG almost completely inhibited the c-Myb-induced proliferation and invasion whereas sulforaphane also had significant inhibitory effect. Both compounds significantly sensitized OC cells to cisplatin, reversing the c-Myb effects. Higher c-Myb levels in patients with ovarian cancer lead to poor survival and our results indicate a possible effect of dietary factors EGCG and sulforaphane against c-Mybmediated ovarian cancer progression and chemoresistance.

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Modulation of Myb‐induced NF‐kB ‐STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors

Tian

Qiao

et al. 2019

Journal Cellular Physiology

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No improvement in long-term survival for epithelial ovarian cancer patients: A population-based study between 1989 and 2014 in the Netherlands

Timmermans

Sonke

Vijver

et al. 2018

European Journal of Cancer

109

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Medical therapy for preventing recurrent endometriosis after conservative surgery: a cost‐effectiveness analysis

Wu¹,

Yang²,

Tobe

et al. 2017

BJOG

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Dr Man-Kai Wan and the medical students of the Hong Kong College of Medicine at Nethersole Hospital in 1898

Cited by 7 publications

References 0 publications

Modulation of Myb‐induced NF‐kB ‐STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors

Modulation of Myb‐induced NF‐kB ‐STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors

No improvement in long-term survival for epithelial ovarian cancer patients: A population-based study between 1989 and 2014 in the Netherlands

Medical therapy for preventing recurrent endometriosis after conservative surgery: a cost‐effectiveness analysis

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