Dr. Pagnoux, et al reply

A study on the aqueous dispersion mechanism of CuO powders using Tiron

“…The sulfonic acid sites easily give up their protons, resulting in very low pK a 1 and pK a 2 values, usually not reported [22]; pK values associated to the hydroxylic acid sites are pK a 3 = 7.7 and pK a 4 = 12.6 [23]. It is an efficient complexing agent for several metallic cations, which enhances its adsorption ability onto particles surfaces of the corresponding metal oxides [24]. Namely, Tiron is well known as an extremely effective anionic dispersant in aqueous media for Al 2 O 3 [17,18,24], ZrO 2 [24] and TiO 2 [24,25]: the alcohol groups are very efficient in complexing metallic cations, leading to chemisorption of the molecule onto the corresponding metallic oxide surface [19,24,26].…”

“…It is an efficient complexing agent for several metallic cations, which enhances its adsorption ability onto particles surfaces of the corresponding metal oxides [24]. Namely, Tiron is well known as an extremely effective anionic dispersant in aqueous media for Al 2 O 3 [17,18,24], ZrO 2 [24] and TiO 2 [24,25]: the alcohol groups are very efficient in complexing metallic cations, leading to chemisorption of the molecule onto the corresponding metallic oxide surface [19,24,26]. Additionally, the ionizable sulfonate groups lead to negative charge development [26] and Na + cations coordinate around complexes assisting in their stabilization [17].…”

Granulomatosis with Polyangiitis (Wegener's Granulomatosis): Evolving Concepts in Treatment

“…65 years old) were randomized to CS for approximately 9 months þ IV pulse CYC 500 mg every 2 to 3 weeks until CR was achieved; maintenance AZA or MTX was then given. 198 The control group received 26 months of CS, combined with IV pulse CYC (500 mg/m 2 every 2 to 3 weeks). 198 The primary outcome measure was more than one serious adverse event (SAE) within 3 years of follow-up.…”

“…198 The control group received 26 months of CS, combined with IV pulse CYC (500 mg/m 2 every 2 to 3 weeks). 198 The primary outcome measure was more than one serious adverse event (SAE) within 3 years of follow-up. Secondary outcome measures included remission and relapse rates.…”

International guidelines for the management ofANCA-associated systemic vasculitides

“…Неотъемлемой частью индукционной и поддерживающей терапии АНЦА-СВ, как стандартной, так и с применением РТМ, по-прежнему остаются глюкокортикоиды (ГК), в том числе в сверхвысоких дозах, во многом обусловливающих спектр НР лечения. В режиме монотерапии ГК не оказывают существенного влияния на прогноз АНЦА-СВ [9], от дозы ГК не зависят частота и скорость развития рецидива АНЦА-СВ [10,11]. Вместе с тем ГК сохраняют свое значение как важная составляющая индукционной и поддерживающей схем лечения, поскольку способны быстро подавлять воспалительные реакции, предотвращать необратимое повреждение органов и создавать коридор возможно-С О В P E М Е Н Н А Я Р Е В М А Т О Л О Г И Я № 1 ' 1 9 К Л И Н И Ч Е С К И Е Р Е К О М Е Н Д А Ц И И стей для эффектов циклофосфана (ЦФ) и РТМ, реализующихся постепенно.…”