Dr2?negative Narcolepsy

Andreas-Zietz, A.; Scholz, Siegfried; Keller, E.; Albert, E. D.; Roth, B; Nevsímalová, S; Šonka, Karel; P, Docekal; Ivasková, E; Schulz, Hartmut; Geisler, Peter

doi:10.1016/s0140-6736(86)90188-1

Cited by 42 publications

(3 citation statements)

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“…Perhaps the most common remaining cause of hypersomnolence is narcolepsy,122although this diagnosis is usually suggested clinically by the other parts of the triad—cataplexy and sleep paralysis. The diagnosis of classic narcolepsy can be secured by demonstration of the HLA-DR2 antigen or its subtypes,124 but, rarely, DR2 studies are negative 125…”

Section: Sleep Related Disordersmentioning

confidence: 99%

Respiratory aspects of neurological disease

Polkey

Lyall

Moxham

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

107

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Section: Sleep Related Disordersmentioning

confidence: 99%

Respiratory aspects of neurological disease

Polkey

Lyall

Moxham

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

107

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“…The extremely strong association between narcolepsy and HLA-DR2 has been one of the major topics in the clinical research on HLA , Langdon et al 1984, Matsuki et al 1985, Billiard & Seignalet 1985, Poirier et al 1986, Mueller-Eckhardt et al 1986. Andreas-Zietz et al 1986, Doran et al 1986).…”

mentioning

confidence: 99%

“…Although there is agreement that this is the strongest HLA-disease association, controversy remains as to whether this association is complete. Recent reports have documented possible cases of DR2-negative narcolepsy, including one Black in England (Langdon et al 1986), one American (Guilleminault & Grumet 1986), one German (Mueller-Eckhardt et al 1986, Andreas-Zietz et al 1986, and one Czechoslovakian (Andreas-Zietz et al 1986). In Japan, however, we have HLAtyped 190 narcoleptics to date, and still have not found a DR2-negative patient (Matsuki et al, in press).…”

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confidence: 99%

Diagnostic criteria for narcolepsy and HLA‐DR2 frequencies

Matsuki¹,

Honda

Juji³

1987

Tissue Antigens

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HLA-DR2 frequencies were investigated in Japanese patients with narcolepsy as defined by various diagnostic criteria. The DR2 frequency was 100% when our criteria for narcolepsy were employed. The use of other criteria that lacked cataplexy as an obligatory symptom, however, reduced the DR2 frequency and led to an apparent "discovery" of DR2-negative cases with "narcolepsy". This ohservation indicates the necessity of precise diagnostic criteria in research on the HLAnarcolepsy association.

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HLA‐DR restriction‐fragment‐length polymorphisms in narcolepsy

Holloman

Bell

Kilduff

et al. 1987

J of Neuroscience Research

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Seventeen white patients from the Stanford Sleep Disorders Clinic complaining of excessive daytime somnolence (EDS) were selected for restriction-fragment-length polymorphism (RFLP) studies. Fourteen of the patients with clinically diagnosed narcolepsy were seropositive for DR2. RFLP analysis of these patients compared with a homozygous DR2-Dw2 cell line failed to reveal any polymorphism when digested with six restriction endonucleases and hybridized with three different cDNA probes. None of the three patients with central nervous system hypersomnia, a syndrome similar to narcolepsy, were DR2-positive. We conclude that any polymorphism of the DR beta, DQ alpha, or DQ beta genes of DR2 narcoleptics that might distinguish them from DR2 normals cannot be resolved through RFLP analysis.

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Dr2?negative Narcolepsy

Cited by 42 publications

References 0 publications

Respiratory aspects of neurological disease

Respiratory aspects of neurological disease

Diagnostic criteria for narcolepsy and HLA‐DR2 frequencies

HLA‐DR restriction‐fragment‐length polymorphisms in narcolepsy

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