Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats

Xiong, Zongliang; Huo, Mohan; Jia, Yongzhen; Zhou, Chong; Ma, Xianglin; Yin, Hang; Jiang, Xiaowen; Yu, Wenhui

doi:10.1155/2022/9050686

Cited by 4 publications

(3 citation statements)

References 53 publications

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“…It was noted that comparing with the model group, the expressions of both EGF and bFGF were significantly increased after 21 days in both inflammation targeting and non-targeting emulsion gel groups ( p < 0.05), whereas the expression of EGF was significantly increased after 14 days in inflammation, targeting the emulsion gel group (* p < 0.05). All these findings indicated that dracorhodin perchlorate could promote the expression of both EGF and bFGF in the wound tissues [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Moreover, inflammation-targeted emulsion gel was observed to be more suitable for use because of its potent inflammation targeting properties.…”

Section: Resultsmentioning

confidence: 99%

Pharmacodynamics of Dracorhodin Perchlorate and Its Inflammation-Targeting Emulsion Gel for Wound Healing

Wang

Xue

Rong

et al. 2022

Gels

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The mechanism of dracorhodin perchlorate for the repair of rat skin wounds was investigated. In order to screen a more favorable drug delivery system for wound repair, the therapeutic effect of dracorhodin perchlorate inflammation-targeted emulsion gel was compared with that of non-targeted emulsion gel on rat wounds. Compared with non-targeted emulsion gels, inflammation-targeted emulsion gels had a better transdermal penetration and lower potentials (−51.6 mV and −17.1 mV, respectively). The recovery of the wound from the dracorhodin perchlorate inflammation targeted emulsion gel group was better than that of the dracorhodin perchlorate inflammation non-targeted emulsion gel group and the positive drug group. Compared with the no-target emulsion gel group, the bFGF expression on day 7 and the EGF expression on day 14 in the targeted emulsion group showed 45.5% and 49.9% improvement, respectively. Pathological tissue slices showed that the epidermis, dermis, and basal layer inflammatory cells in the inflammation-targeted emulsion gel group and non-targeted emulsion gel group were significantly reduced, the granulation tissue proliferation was obvious, and the inflammation-targeted emulsion gel group was more effective. The results proved that dracorhodin perchlorate had a repairing effect on rat skin wounds, and its mechanism might be related to the promotion of the expression of EGF and bFGF in tissues.

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Section: Resultsmentioning

confidence: 99%

Pharmacodynamics of Dracorhodin Perchlorate and Its Inflammation-Targeting Emulsion Gel for Wound Healing

Wang

Xue

Rong

et al. 2022

Gels

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“…Among these components, dracorhodin and rhein were characteristic. Dracorhodin could promote the proliferation of fibroblasts [ 32 ] and keratinocytes [ 33 ] during wound healing. In addition, dracorhodin can inhibit the secretion of IL-1α and TNF-α, alleviate inflammation, stimulate the expression of vascular endothelial growth factors and TGF, and promote fibroblast proliferation and collagen deposition [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Research on the wound healing effect of Shengji Huayu Formula ethanol extract-derived fractions in streptozotocin-induced diabetic ulcer rats

Zhang

et al. 2023

BMC Complement Med Ther

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Background Diabetic ulcer is a common complication of diabetes. It is characterized by a long-term disease course and high recurrence rate. Shengji Huayu Formula (SHF) is an effective formula for treating diabetic ulcers. However, the specific effective parts of SHF remain unclear. Clarifying the active polar site of SHF would be helpful to refine research on the components in SHF that promote wound healing. This research aims to focus on evaluating the activity of polar fractions. Methods A diabetic rat model was established by intraperitoneally injecting streptozotocin (STZ) and was adopted to confirm the therapeutic effect of SHF. Four different polarity parts were extracted from SHF and prepared into a cream to evaluate the activity. High-performance liquid chromatography (HPLC) was used to detect chemical constituents in chloroform extracts. Results It was discovered that dracorhodin, aloe-emodin, rhein, imperatorin, emodin, isoimperatorin, chrysophanol, physcion, and tanshinone IIA were the main components of the chloroform extract from SHF. The results revealed that chloroform extract could effectively accelerate diabetic wound healing by promoting collagen regeneration and epidermal repair. Chloroform extract of SHF could stimulate the generation of vascular endothelial growth factor (VEGF). The results are also indicated that the effective active fraction was the chloroform part, and the method of detecting the main chemical constituents in the active part was successfully established. Conclusion SHF could improve diabetic ulcers by promoting granulation tissue synthesis. In this study, four polar parts (petroleum ether, chloroform, ethylacetate, n-butanol) were extracted from a 95% ethanol extract. In contrast, chloroform polar parts showed a higher wound closure rate, stimulated more collagen regeneration and promoted more production of vascular endothelial cells. In conclusion, the chloroform extract of SHF was the effective polar part in ameliorating diabetic wound healing.

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“…Recent studies have confirmed that DP can promote fibroblast proliferation, collagen formation, and inhibit scar growth; accordingly, it is widely used in scarless wound healing (Jiang et al, 2018;Jiang et al, 2017;Lu et al, 2021;Xiong et al, 2022). Moreover, it is often used as adjuvant treatment for refractory wounds (Lingli et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Multifunctional all-in-one adhesive hydrogel for the treatment of perianal infectious wounds

Yin

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Postoperative wound of perianal infectious disease represents a common but unique refractory wound in clinical practice. The reasons that hinder the wound healing process include not only the severe bacterial infection of the wound itself and the narrow and deep shape of the wound, but also its frequent bacterial contact. Therefore, the development of biofunctional dressings to aid in therapy is essential. In this study, we synthesized a new type of dressing comprising a hydrogel host based on the Schiff base principle and catechol groups between polydopamine, oxidized dextran, and quaternized chitosan, and then loaded it with traditional Chinese medicine molecules. These formed an integrated hydrogel for accelerated wound repair in a perianal infection model. The prepared hydrogels exhibited excellent wet tissue adhesion, antifouling, morphological variability, suitable swelling properties, and complete degradability, as well as remarkable contact antibacterial ability and the ability to rapidly scavenge free radicals. Hemostatic experiments showed excellent hemostatic properties, as the integrated hydrogel could instantly gel to seal the hemorrhage. Hemocompatibility and in vitro cell experiments showed that the integrated hydrogel had good biosafety and significantly promoted cell proliferation, which in turn accelerated the repair of infected whole cortexes in rats. A histomorphological evaluation showed that the integrated hydrogel promoted the recovery of normal anatomical tissue in rats by promoting the formation of collagen fibers and inhibiting inflammation. The results showed that this multifunctional integrated hydrogel has great potential for the treatment of continuously infected skin regeneration, providing a promising therapeutic strategy for postoperative wound healing in perianal infectious diseases.

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Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats

Cited by 4 publications

References 53 publications

Pharmacodynamics of Dracorhodin Perchlorate and Its Inflammation-Targeting Emulsion Gel for Wound Healing

Pharmacodynamics of Dracorhodin Perchlorate and Its Inflammation-Targeting Emulsion Gel for Wound Healing

Research on the wound healing effect of Shengji Huayu Formula ethanol extract-derived fractions in streptozotocin-induced diabetic ulcer rats

Multifunctional all-in-one adhesive hydrogel for the treatment of perianal infectious wounds

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