Draft genome of the river water buffalo

Mintoo, Abdul Awal; Zhang, Hailin; Chen, Chunhai; Moniruzzaman, Mohammad; Deng, Tingxian; Anam, Mahbub; Huque, Q. M. E.; Guang, Xuanmin; Wang, Ping; Zhong, Zhisheng; Han, Pengfei; Khatun, Asma; Awal, Tabith M.; Gao, Qiang; Liang, Xianwei

doi:10.1002/ece3.4965

Cited by 36 publications

(30 citation statements)

References 55 publications

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“…Water buffalo and cattle are estimated to have last had a common ancestor over 5.8 million years ago 36 . However, since domestication humans have exerted strong artificial selection on both species for similar traits.…”

Section: Discussionmentioning

confidence: 99%

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

et al. 2020

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More people globally depend on the water buffalo than any other domesticated species, and as the most closely related domesticated species to cattle they can provide important insights into the shared evolutionary basis of domestication. Here, we sequence the genomes of 79 water buffalo across seven breeds and compare patterns of between breed selective sweeps with those seen for 294 cattle genomes representing 13 global breeds. The genomic regions under selection between cattle breeds significantly overlap regions linked to stature in human genetic studies, with a disproportionate number of these loci also shown to be under selection between water buffalo breeds. Investigation of potential functional variants in the water buffalo genome identifies a rare example of convergent domestication down to the same mutation having independently occurred and been selected for across domesticated species. Cross-species comparisons of recent selective sweeps can consequently help identify and refine important loci linked to domestication.

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Section: Discussionmentioning

confidence: 99%

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

et al. 2020

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“…In this study, we performed a genome-wide detection and identification of eight DGAT family genes from the first complete genome of buffalo (UOA_WB_1 assembly) [22] and the latest genome version of cattle (ARS-UCD1.2 assembly). Among eight buffalo DGATs, DGAT1 belongs to the DGAT1 subfamily, and the DGAT2 subfamily consisted of DGAT2, MOGAT1, MOGAT2, MOGAT3, AWAT1, AW AT2, and DGAT2L6.…”

Section: Structural Features Of Buffalo Dgat Family Proteins and Genesmentioning

confidence: 99%

“…The recent completion of the buffalo genome sequence made the genome-wide identification of buffalo family genes possible [22]. Therefore, the present study aimed to detect DGAT family genes in the buffalo genome, and then perform a detailed analysis of the classification, physicochemical properties, phylogenetic analysis, structural features, and functional analysis.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide identification of Diacylglycerol Acyltransferases (DGAT) family genes influencing Milk production in Buffalo

Liu

Wang

et al. 2020

BMC Genet

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Background: The diacylglycerol acyltransferases (DGAT) are a vital group of enzymes in catalyzing triacylglycerol biosynthesis. DGAT genes like DGAT1 and DGAT2, have been identified as two functional candidate genes affecting milk production traits, especially for fat content in milk. Buffalo milk is famous for its excellent quality, which is rich in fat and protein content. Therefore, this study aimed to characterize DGAT family genes in buffalo and to find candidate markers or DGAT genes influencing lactation performance. Results: We performed a genome-wide study and identified eight DGAT genes in buffalo. All the DGAT genes classified into two distinct clades (DGAT1 and DGAT2 subfamily) based on their phylogenetic relationships and structural features. Chromosome localization displayed eight buffalo DGAT genes distributed on five chromosomes. Collinearity analysis revealed that the DGAT family genes were extensive homologous between buffalo and cattle. Afterward, we discovered genetic variants loci within the genomic regions that DGAT genes located in buffalo. Seven haplotype blocks were constructed and were associated with buffalo milk production traits. Single marker association analyses revealed four most significant single nucleotide polymorphisms (SNPs) mainly affecting milk protein percentage or milk fat yield in buffalo. Genes functional analysis indicated that these DGAT family genes could influence lactation performance in the mammal through regulating lipid metabolism.Conclusion: In the present study, we performed a comprehensive analysis for the DGAT family genes in buffalo, which including identification, structural characterization, phylogenetic classification, chromosomal distribution, collinearity analysis, association analysis, and functional analysis. These findings provide useful information for an in-depth study to determine the role of DGAT family gens play in the regulation of milk production and milk quality improvement in buffalo.

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“…In this study, we performed a genome-wide detection and identification of eight DGAT family genes from the first complete genome of buffalo (UOA_WB_1 assembly) [22] DGAT enzymes activities are mostly dependent on their functional motifs and domains in the proteins.…”

Section: Structural Features Of Buffalo Dgat Family Proteins and Genesmentioning

confidence: 99%

Genome-wide identification of diacylglycerol acyltransferases (DGAT) family genes influencing milk production traits in buffalo

Liu

Wang

et al. 2020

Preprint

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Background: The diacylglycerol acyltransferases (DGAT) are a vital group of enzymes in catalyzing triacylglycerol biosynthesis. DGAT genes like DGAT1 and DGAT2 , have been identified as two functional candidate genes affecting milk production traits, especially for fat content in milk. Buffalo milk is famous for its excellent quality, which is rich in fat and protein content. Therefore, this study aimed to characterize DGAT family genes in buffalo and to find candidate markers or DGAT genes influencing lactation performance. Results: We performed a genome-wide study and identified eight DGAT genes in buffalo. All the DGAT genes classified into two distinct clades (DGAT1 and DGAT2 subfamily) based on their phylogenetic relationships and structural features. Chromosome localization displayed eight buffalo DGAT genes distributed on five chromosomes. Collinearity analysis revealed that the DGAT family genes were extensive homologous between buffalo and cattle. Afterward, we discovered genetic variants loci within the genomic regions that DGAT genes located in buffalo. Seven haplotype blocks were constructed and were associated with buffalo milk production traits. Single marker association analyses revealed four most significant single nucleotide polymorphisms (SNPs) mainly affecting milk protein percentage or milk fat yield in buffalo. Genes functional analysis indicated that these DGAT family genes could influence lactation performance in the mammal through regulating lipid metabolism. Conclusion: In the present study, we performed a comprehensive analysis for the DGAT family genes in buffalo, which including identification, structural characterization, phylogenetic classification, chromosomal distribution, collinearity analysis, association analysis, and functional analysis. These findings provide useful information for an in-depth study to determine the role of DGAT family gens play in the regulation of milk production and milk quality improvement in buffalo.

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Draft genome of the river water buffalo

Cited by 36 publications

References 55 publications

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication

Genome-wide identification of Diacylglycerol Acyltransferases (DGAT) family genes influencing Milk production in Buffalo

Genome-wide identification of diacylglycerol acyltransferases (DGAT) family genes influencing milk production traits in buffalo

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