Draft Genome Sequence of
            <i>Chryseobacterium</i>
            sp. Strain P1-3, a Keratinolytic Bacterium Isolated from Poultry Waste

Park, Gun-Seok; Hong, Sung-Jun; Lee, Chang‐Hyun; Khan, Abdur Rahim; Ullah, Ihsan; Jung, Byung Kwon; Choi, Jin Woo; Kwak, Yunyoung; Back, Chang–Gi; Jung, Hee‐Young; Shin, Jae‐Ho

doi:10.1128/genomea.01237-14

Cited by 9 publications

(6 citation statements)

References 13 publications

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“…Including: (i) Chryseobacterium camelliae Dolsongi-HT1, isolated from green tea leaves [ 48 ]; (ii) Chryseobacterium gallinarum strain DSM 27622, isolated from chicken [ 49 ]; and (iii) Chryseobacterium sp. P1-3 isolated from poultry waste [ 50 ], which all display keratinolytic capacity. Chryseobacterium sp.…”

Section: Resultsmentioning

confidence: 99%

Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production

et al. 2021

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A promising keratin-degrading strain from the genus Chryseobacterium (Chryseobacterium sp. KMC2) was investigated using comparative genomic tools against three publicly available reference genomes to reveal the keratinolytic potential for biosynthesis of valuable secondary metabolites. Genomic features and metabolic potential of four species were compared, showing genomic differences but similar functional categories. Eleven different secondary metabolite gene clusters of interest were mined from the four genomes successfully, including five common ones shared across all genomes. Among the common metabolites, we identified gene clusters involved in biosynthesis of flexirubin-type pigment, microviridin, and siderophore, showing remarkable conservation across the four genomes. Unique secondary metabolite gene clusters were also discovered, for example, ladderane from Chryseobacterium sp. KMC2. Additionally, this study provides a more comprehensive understanding of the potential metabolic pathways of keratin utilization in Chryseobacterium sp. KMC2, with the involvement of amino acid metabolism, TCA cycle, glycolysis/gluconeogenesis, propanoate metabolism, and sulfate reduction. This work uncovers the biosynthesis of secondary metabolite gene clusters from four keratinolytic Chryseobacterium species and shades lights on the keratinolytic potential of Chryseobacterium sp. KMC2 from a genome-mining perspective, can provide alternatives to valorize keratinous materials into high-value bioactive natural products.

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Section: Resultsmentioning

confidence: 99%

Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production

et al. 2021

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“…Including: i) Chryseobacterium camelliae Dolsongi-HT, isolated from green tea leaves (29); ii) Chryseobacterium gallinarum strain DSM 27622, isolated from chicken (30); and iii) Chryseobacterium sp. strain P1-3 isolated from poultry waste (31), which all display keratinolytic capacity (Table 1). Chryseobacterium sp.…”

Section: Resultsmentioning

confidence: 99%

“…Although the keratinolytic capacity within these eight strains is still not clear, more keratinolytic species are expected to be found in this genus according to the phylogenic tree analysis. Four strains among this genus have documented with actual keratin degradation capability (29-31), while Chryseobacterium sp. KMC2 may possess different keratinolytic potential encoded in its larger genome compared to three other Chryseobacterium strains.…”

Section: Resultsmentioning

confidence: 99%

Comparative genomics analysis of Chryseobacterium sp. KMC2 reveals metabolic pathways involved in keratinous utilization and natural product biosynthesis

Kang

Shoaie

Jacquiod

et al. 2021

Preprint

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Several efforts have been made to valorize keratinous materials, an abundant and renewable resource. Despite these attempts to valorize products generated from keratin hydrolysate, either via chemical or microbial conversion, they generally remain with an overall low value. In this study, a promising keratinolytic strain from the genus Chryseobacterium (Chryseobacteriumsp. KMC2) was investigated using comparative genomic tools against publicly available reference genomes to reveal the metabolic potential for biosynthesis of valuable secondary metabolites. Genome and metabolic features of four species were compared, shows different gene numbers but similar functional categories. We successfully mined eleven different secondary metabolite gene clusters of interest from the four genomes, including five common ones shared across all genomes. Among the common metabolites, we identified gene clusters involved in biosynthesis of flexirubin-type pigment, microviridin, and siderophore, all showing remarkable conservation across the four genomes. Unique secondary metabolite gene clusters were also discovered, for example, ladderane from Chryseobacterium sp. KMC2. Additionally, this study provides a more comprehensive understanding of the potential metabolic pathways of keratin utilization in Chryseobacterium sp. KMC2, with the involvement of amino acid metabolism, TCA cycle, glycolysis/gluconeogenesis, propanoate metabolism, and sulfate reduction. This work uncovers the biosynthesis of secondary metabolite gene clusters from four keratinolytic Chryseobacterium spp. and shades lights on the keratinolytic potential of Chryseobacterium sp. KMC2 from a genome-mining perspective, providing alternatives to valorize keratinous materials into high-value natural products.

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“…Bacterial species belonging to the genus Chryseobacterium were isolated from various environments such as fishes ( 1 ), humans ( 2 ), water-cooling systems ( 3 ), poultry ( 4 ), within production lines of food manufacturing companies ( 5 ), etc. In addition, some Chryseobacterium strains were isolated from the rhizosphere soils of different plants including potato ( 6 ), eggplant ( 7 ), wild rye and wild pea ( 8 ), cempedak ( 9 ), or garden lettuce ( 10 ).…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of Chryseobacterium sp. JV274 Isolated from Maize Rhizosphere

et al. 2017

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Draft Genome Sequence of Chryseobacterium sp. Strain P1-3, a Keratinolytic Bacterium Isolated from Poultry Waste

Abstract: Chryseobacterium sp. strain P1-3, harboring keratin degrading activity, has recently been isolated from poultry waste. Here, we report the 4.6-Mbp draft genome sequence of the keratinolytic bacterium with a G+C content of 37.0% and 4,087 protein-coding genes.

Cited by 9 publications

References 13 publications

Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production

Comparative Genomics Analysis of Keratin-Degrading Chryseobacterium Species Reveals Their Keratinolytic Potential for Secondary Metabolite Production

Comparative genomics analysis of Chryseobacterium sp. KMC2 reveals metabolic pathways involved in keratinous utilization and natural product biosynthesis

Draft Genome Sequence of Chryseobacterium sp. JV274 Isolated from Maize Rhizosphere

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