Draft Genome Sequence of
            <i>Nocardia jinanensis</i>
            , an Opportunistic Bacterial Pathogen That Causes Cellulitis

Chakrabortti, Alolika; Li, Jinming; Liang, Zhao‐Xun

doi:10.1128/genomea.00593-16

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Multiple gene clusters for secondary metabolism appear also to be a hallmark of several non‐ Streptomyces filamentous actinobacteria and of the myxobacteria . Chakrabortti et al identified eight NRPS gene clusters and two PKS gene clusters in the genome of N. jinanensis .…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial potential of haloalkaliphilic Nocardiopsis sp. AJ1 isolated from solar salterns in India

et al. 2019

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Antagonistic haloalkaliphilic Nocardiopsis sp. AJ1 (GenBank JX575136.1), isolated and identified from the saline soil of Kovalam solar salterns was able to produce antimicrobial secondary metabolites and effectively suppressed several bacterial and fungal pathogens. The metabolite extracted from ethyl acetate precipitation suppressed the bacterial and fungal pathogens to the range between 2.14 and 20.14 mm and also controlled the shrimp killer virus WSSV by 83% than the control and significantly (p < 0.05) differed. GC-MS analysis revealed that, the ethyl acetate precipitation contains pyrrolo (1,2-A(pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-) and actinomycin C2. Non ribosomal peptide synthetase (NRPS) was amplified by PCR with the amplicon size of 750-800 bp length and further predicted the secondary structure by Iterative Threading Assembly Refinement (I-TASSER) bioinformatics approach. I-TASSER prediction helped to find out the secondary, 3-D structure, and ligand binding sites. The top ten modelling concluded that, the NRPS gene is closely similar to surfactin synthesizing gene, surfactin A synthetase C (SRFA-C). The findings revealed that, the active compounds from the secondary metabolites effectively suppressed the pathogenic bacteria, fungi, and virus and useful to develop antimicrobials. K E Y W O R D S actinobacteria, antimicrobials, haloalkaliphils, Nocardiopsis sp. AJ1, non ribosomal peptide synthetase (NRPS)

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Section: Discussionmentioning

confidence: 99%

Antimicrobial potential of haloalkaliphilic Nocardiopsis sp. AJ1 isolated from solar salterns in India

et al. 2019

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“…Multiple genome sequences of different species of Nocardia have been reported till date. These sequences provide insights about different virulence factors which are known to play crucial role in cell invasion, modulation of phagocyte functions and survival inside the host macrophages resulting successful pathogenesis [14][15][16][17][18][19]. Not just the genomes of pathogenic species of Nocardia, but species of Nocardia that are known to be endophytes, has also been studied to explore their biological roles [20,21].…”

Section: Introductionmentioning

confidence: 99%

Insights from the comparative genome analysis of natural rubber degrading Nocardia species

Sarkar¹

2021

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Nocardia are known to be a facultative human pathogen and can cause infection in immune compromised patients. Though the details research on the virulence factors of Nocardia are scanty but numerous genes that code such factors were reported from different species of Nocardia. Despite of the presence of several virulence factors, species of this genus have been shown to have role in remediation of many toxic and hazardous materials from the environment. In this study, genome sequences of rubber degrading Nocardia sp. BSTN01 and N. nova SH22a have been analyzed to locate the potential virulence genes. Also, the genomes of facultative pathogenic Nocardia like, N. africana, N. brasiliensis, N. kruczakiae, N. transvalensis and N. veterana have been analyzed to find the gene encoding latex clearing protein (Lcp), a rubber oxygenase enzyme of Gram-positive action bacteria. The study provides an insight about the potentiality of rubber-degrading Nocardia species to emerge as future human pathogens and also the probability of a serious concern if the studied facultative pathogens of Nocardia like N. africana, N. brasiliensis, N. kruczakiae, N. transvalensis and N. veteranaare capable of degrading rubber, a regularly used material in clinics. Moreover, use of such possible pathogenic strains for their known role in bioremediation of rubber waste from the environment might be deleterious.

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Draft Genome Sequence of Nocardia jinanensis , an Opportunistic Bacterial Pathogen That Causes Cellulitis

Cited by 2 publications

References 7 publications

Antimicrobial potential of haloalkaliphilic Nocardiopsis sp. AJ1 isolated from solar salterns in India

Antimicrobial potential of haloalkaliphilic Nocardiopsis sp. AJ1 isolated from solar salterns in India

Insights from the comparative genome analysis of natural rubber degrading Nocardia species

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