Draft Genome Sequence of Marine-Derived Actinomycete
            <i>Nocardiopsis</i>
            sp. Strain TP-A0876, a Producer of Polyketide Pyrones

Komaki, Hisayuki; Ichikawa, Natsuko; Hosoyama, Akira; Fujita, Nobuyuki; Igarashi, Yasuhiro

doi:10.1128/genomea.00665-14

Cited by 11 publications

(13 citation statements)

References 14 publications

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“…; Komaki et al . ). Pyrone derivatives are a class of important secondary metabolites synthesized via such PKS gene clusters (Busch and Hertweck ).…”

Section: Polyketide Structure‐based Antibioticsmentioning

confidence: 97%

“…It must be noted that NRPS genes are present in Nocardiopsis species (Komaki et al . ). These gene clusters could be involved in the synthesis of such peptides.…”

Section: Cyclic Peptides With No Reported Activitymentioning

confidence: 97%

“…Recently, Komaki et al . () have shown that the ncpA‐D gene cluster in N. alba CR167 is homologous to a type‐I PKS gene cluster in another marine Nocardiopisis sp. (TP‐A0876).…”

Section: Anticancer and Antitumour Compoundsmentioning

confidence: 99%

“…Clinically significant drugs such as tetracycline, daunorubicin, erythromycin, rapamycin and lovastatin, to mention a few, are biosynthesized from acyl CoA precursors by polyketide synthases, PKSs (Shen 2003). Nocardiopsis species harbour different types of PKS gene clusters that help them in producing an array of natural products Komaki et al 2014). Pyrone derivatives are a class of important secondary metabolites synthesized via such PKS gene clusters (Busch and Hertweck 2009).…”

Section: Polyketide Structure-based Antibioticsmentioning

confidence: 99%

“…In general, nonribosomal peptide synthetase (NRPS) gene clusters are involved in the production of cyclic peptides (Finking and Marahiel 2004). It must be noted that NRPS genes are present in Nocardiopsis species (Komaki et al 2014). These gene clusters could be involved in the synthesis of such peptides.…”

Section: Cyclic Peptides With No Reported Activitymentioning

confidence: 99%

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Nocardiopsisspecies: a potential source of bioactive compounds

et al. 2015

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Summary Members of the genus Nocardiopsis are an ecologically versatile and biotechnologically important group of Actinomycetes. Most of the isolates are halotolerant or halophilic and they prevail in soils, marine environments or hypersaline locations. To aid their survival under these conditions, they mainly produce extremozymes, compatible solutes, surfactants and bioactive compounds. The current review details the bioactive compounds obtained for this genus. Important antimicrobial agents obtained from this genus include polyketides, phenzines, quinoline alkaloids, terphenyls, proteins, thiopeptides and amines. Polyketides and peptides displaying potent anticancer activities are also significant. Tumour promoting agents, P‐glycoprotein (P‐gp) inhibitors, immunomodulators and protein kinase inhibitors are other relevant products obtained from Nocardiopsis species. Structurally, polyketides (synthesized by polyketide synthases) and peptides (made by nonribosomal peptide synthetases or cyclodipeptide synthases) are important compounds. Considered here are also toxins, anti photoaging and adipogenic agents produced by this genus. The gene clusters mediating the synthesis of bioactive compounds have been described. Commercially available products (Apoptolidins and K‐252a) derived from this genus have also been described. This review highlights the significance of a single genus in producing an assortment of compounds with varied biological activities. On account of these features, the members of this genus have established a place for themselves and are of considerable value in producing compounds with profound bio‐medical applications.

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“…; Komaki et al . ). Pyrone derivatives are a class of important secondary metabolites synthesized via such PKS gene clusters (Busch and Hertweck ).…”

Section: Polyketide Structure‐based Antibioticsmentioning

confidence: 97%

“…It must be noted that NRPS genes are present in Nocardiopsis species (Komaki et al . ). These gene clusters could be involved in the synthesis of such peptides.…”

Section: Cyclic Peptides With No Reported Activitymentioning

confidence: 97%

“…Recently, Komaki et al . () have shown that the ncpA‐D gene cluster in N. alba CR167 is homologous to a type‐I PKS gene cluster in another marine Nocardiopisis sp. (TP‐A0876).…”

Section: Anticancer and Antitumour Compoundsmentioning

confidence: 99%

Section: Polyketide Structure-based Antibioticsmentioning

confidence: 99%

Section: Cyclic Peptides With No Reported Activitymentioning

confidence: 99%

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Nocardiopsisspecies: a potential source of bioactive compounds

et al. 2015

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Antimicrobial potential of haloalkaliphilic Nocardiopsis sp. AJ1 isolated from solar salterns in India

et al. 2019

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Antagonistic haloalkaliphilic Nocardiopsis sp. AJ1 (GenBank JX575136.1), isolated and identified from the saline soil of Kovalam solar salterns was able to produce antimicrobial secondary metabolites and effectively suppressed several bacterial and fungal pathogens. The metabolite extracted from ethyl acetate precipitation suppressed the bacterial and fungal pathogens to the range between 2.14 and 20.14 mm and also controlled the shrimp killer virus WSSV by 83% than the control and significantly (p < 0.05) differed. GC-MS analysis revealed that, the ethyl acetate precipitation contains pyrrolo (1,2-A(pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-) and actinomycin C2. Non ribosomal peptide synthetase (NRPS) was amplified by PCR with the amplicon size of 750-800 bp length and further predicted the secondary structure by Iterative Threading Assembly Refinement (I-TASSER) bioinformatics approach. I-TASSER prediction helped to find out the secondary, 3-D structure, and ligand binding sites. The top ten modelling concluded that, the NRPS gene is closely similar to surfactin synthesizing gene, surfactin A synthetase C (SRFA-C). The findings revealed that, the active compounds from the secondary metabolites effectively suppressed the pathogenic bacteria, fungi, and virus and useful to develop antimicrobials. K E Y W O R D S actinobacteria, antimicrobials, haloalkaliphils, Nocardiopsis sp. AJ1, non ribosomal peptide synthetase (NRPS)

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