“…Chemokines and cytokines also seem to play a role in macrophage activation, granuloma formation, and fibrosis. Individual susceptibility Khoor et al, 17 Morell et al, 28 Fjallbrant et al, 56 Mukhopadhyay, 57 Cormier, 58 Katzenstein and Askin, 79 Barrera et al, 80 Emanuel et al, 81 Nakajima et al, 82 Utsugi et al, 83 Yoo et al, 84 Orriols et al, 85 Jordan and Gey, 86 and Marcer et al 87 is poorly understood. Studies suggest a genetic link to the major histocompatibility complex because certain major histocompatibility complex haplotypes increase a person's susceptibility to developing HP.…”