Draft Genome Sequences of Two Salmonella Strains from the SARA Collection, SARA64 (Muenchen) and SARA33 (Heidelberg), Provide Insight into Their Antibiotic Resistance

Abstract

The Salmonella enterica strains that are representatives of the S. enterica serovar Typhimurium complex in reference collection A (SARA) are closely related but exhibit differences in antibiotic resistance, which could have public health consequences. To better understand the mechanisms behind these resistances, we sequenced the genomes of two multidrug-resistant strains: SARA64 (Muenchen) and SARA33 (Heidelberg).

Applying the ResFinder and VirulenceFinder web-services for easy identification of acquired antibiotic resistance andE. colivirulence genes in bacteriophage and prophage nucleotide sequences

“…A study that compared traditional phenotypic methods for antimicrobial susceptibility testing to the results obtained by ResFinder, showed high concordance (99.74%) between phenotypic and predicted antimicrobial susceptibility. 29 ResFinder has also been used to search for antibiotic resistance genes in Acinetobacter baumannii, 30,31 Escherichia coli, 32 Salmonella enterica, 33,34 and metagenomic samples from permafrost. 35 The database of acquired antibiotic resistance genes, which is the foundation of ResFinder, is compiled from existing databases, e.g., the ARDB (http://ardb.cbcb.umd.edu/) and a thorough literature search.…”