Draft Genome Sequencing of Three Glutaraldehyde-Tolerant Bacteria from Produced Water from Hydraulic Fracturing

Techtmann, Stephen M.; Baldwin, Andrew L; Aluko, Dotun; Andersen, Justin; Becker, Cole; Chandler, G. Scott; Forgrave, Steve; Jones, Madelyn; Klasner, Ina; Martini, Jared; Mason, Noah; Parsons, Ryleigh; Peterson, Nick; Reynolds, Erik; Schroeder, Lydia

doi:10.1128/mra.01232-21

Cited by 1 publication

(1 citation statement)

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“…As already discussed in this review, P. aeruginosa is equipped with a plethora of antimicrobial tolerance mechanisms, and the overexpression of efflux pumps is frequently associated with this problem [ 184 , 185 , 186 , 187 ]. In fact, efflux-pump-mediated resistance towards different classes of biocides, including phenolic compounds [ 188 , 189 , 190 , 191 , 192 , 193 , 194 ], cationic biocides [ 185 , 195 , 196 , 197 , 198 , 199 , 200 ], alkylating agents [ 201 , 202 , 203 , 204 ], and oxidizing compounds [ 173 , 205 ] has already been described.…”

Section: Biocide Tolerancementioning

confidence: 99%

Mechanisms of Antibiotic and Biocide Resistance That Contribute to Pseudomonas aeruginosa Persistence in the Hospital Environment

Verdial¹,

Serrano

Tavares

et al. 2023

Biomedicines

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Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for multiple hospital- and community-acquired infections, both in human and veterinary medicine. P. aeruginosa persistence in clinical settings is worrisome and is a result of its remarkable flexibility and adaptability. This species exhibits several characteristics that allow it to thrive under different environmental conditions, including the ability to colonize inert materials such as medical equipment and hospital surfaces. P. aeruginosa presents several intrinsic mechanisms of defense that allow it to survive external aggressions, but it is also able to develop strategies and evolve into multiple phenotypes to persevere, which include antimicrobial-tolerant strains, persister cells, and biofilms. Currently, these emergent pathogenic strains are a worldwide problem and a major concern. Biocides are frequently used as a complementary/combination strategy to control the dissemination of P. aeruginosa-resistant strains; however, tolerance to commonly used biocides has also already been reported, representing an impediment to the effective elimination of this important pathogen from clinical settings. This review focuses on the characteristics of P. aeruginosa responsible for its persistence in hospital environments, including those associated with its antibiotic and biocide resistance ability.

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