Draft of clinical guidelines for the diagnosis and treatment of differentiated thyroid cancer in adult patients

Choynzonov, E. L.; Решетов, И. В.; Иванов, С. А.; Polyakov, A.; Кропотов, М. А.; Мудунов, А. М.; Полькин, В. В.; Исаев, П. А.; Ilyin, А V; Beltsevich, D. G.; Ванушко, В Э; Rumiantsev, Pavel O.; Melnichenko, G. A.; Alymov, Yu. V.; Романов, И. С.; Игнатова, А. В.; Бородавина, Е. В.; Крылов, В В; Shurinov, A. Yu.; Severskaya, N. V.; Раджабова, З. А.; Kulbakin, D. Е.; Nevolskikh, A. A.; Gevorkov, A. R.; Khmelevsky, E.; Кутукова, Светлана; Guz, A. O.; Sleptsov, Ilya; Chernikov, Roman; Степанова, А. М.; Falaleeva, N. A.; Подвязников, С. О.; Рубцова, Н. А.; Rudyk, A. N.; Musin, Sh. I.; Гулидов, И. А.; Vladimirova, L. Yu.; Semiglazova, T. Yu.; Aghababyan, T. A.; Костромина, Е. В.

doi:10.14341/serg12792

Endo Serg

2023

DOI: 10.14341/serg12792

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Draft of clinical guidelines for the diagnosis and treatment of differentiated thyroid cancer in adult patients

E. L. Choynzonov

И. В. Решетов

С. А. Иванов

et al.

Abstract: The article presents a draft of clinical recommendations for the diagnosis and treatment of differentiated thyroid cancer in adult patients, which provides a modern examination algorithm, discusses the basic principles of laboratory, instrumental diagnostics and treatment approaches.

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Cited by 7 publications

References 52 publications

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Multiple-Instance Learning for thyroid gland disease classification: A hands-on experience

Lysukhin,

Varlamov,

Yakimov

et al. 2025

Computers in Biology and Medicine

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Multiple-Instance Learning for thyroid gland disease classification: A hands-on experience

Lysukhin,

Varlamov,

Yakimov

et al. 2025

Computers in Biology and Medicine

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Guidelines for radioiodine therapy in differentiated thyroid cancer and post-therapeutic follow-up

Shurinov,

Borodavina,

Krylov

et al. 2024

Opuholi golovy i šei

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The radioiodine therapy is a one of the basic elements at combined treatment of differentiated thyroid cancer and is an alternative method for patients with distant metastases and a potentially high risk of tumor recurrence. It has been used in clinical practice for more than 80 years. The first report on the phenomenon of accumulation of 130I/131I in a metastatic focus of differentiated thyroid cancer was published by A. Keston et al. in 1942, and in 1946, the production of 131I was established, and the drug became available. In our country, radioiodine therapy has been widely used for the treatment of differentiated thyroid cancer since 1982.This article presents methodological recommendations for radioiodine therapy of patients with differentiated thyroid cancer, provides a modern examination algorithm, discusses the basic principles of laboratory, instrumental diagnostics and treatment approaches treatment of this disease.

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The use of vacuum fine needle aspiration biopsy of small formations in the diagnosis of thyroid cancer

Tagil,

Borsukov

2024

Opuholi golovy i šei

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Introduction. Diagnosis and treatment of lesional pathology of the thyroid are important problems in Russia and worldwide. Currently, fine-needle aspiration (FNA) is the main technique of differential diagnosis of benign and malignant tumors of the thyroid. In 2023, clinical guidelines of the European Thyroid Association (ETA) on thyroid lesion treatment were published noting possible minimally invasive treatment of benign and malignant tumors of the thyroid requiring repeat cytologic verification. Despite the proven effectiveness of FNA, its informativity and specificity vary between 60 and 100 %. Additionally, this method is associated with high risk of false negative and false positive results. Therefore, there is a need to improve FNA and minimize its disadvantages.Aim. To evaluate the capabilities of vacuum FNA of small lesions using multiparameter ultrasound in diagnosis of thyroid cancer.Materials and methods. At the scientific and practical problem laboratory Diagnostic Studies and Minimally Invasive Technologies of the Smolensk State Medical University, a device for vacuum FNA was developed. Between 2023 and 2024, patients with thyroid lesions of size <10 mm underwent 25 vacuum FNAs. Correlation analysis with 51 FNAs performed between 2020 and 2023 was performed.Results. A decrease in the number of nondiagnostic (category I per the Bethesda system, 2017) and undetermined (category III per the Bethesda system, 2017) results was observed. Comparison of preoperative cytologic conclusions (category V per the Bethesda system, 2017) with the results of postoperative histological examination in patients of the control group showed benign lesions in 2 (50 %) cases which correspond to false negative results. Vacuum FNA did not show this discrepancy. These results demonstrate a decrease in the probability of false negative results and effectiveness of vacuum FNA.Conclusion. Use of vacuum FNA expedites ultrasound-guided biopsy for small thyroid lesions. Due to high negative pressure (up to –0.8 bar), single-step retrieval of cytologic material is performed which leads to a decrease in the number of nondiagnostic and undetermined cytologic conclusions by 11.7 and 1.9 %, respectively.

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Draft of clinical guidelines for the diagnosis and treatment of differentiated thyroid cancer in adult patients

Abstract: The article presents a draft of clinical recommendations for the diagnosis and treatment of differentiated thyroid cancer in adult patients, which provides a modern examination algorithm, discusses the basic principles of laboratory, instrumental diagnostics and treatment approaches.

Cited by 7 publications

References 52 publications

Multiple-Instance Learning for thyroid gland disease classification: A hands-on experience

Multiple-Instance Learning for thyroid gland disease classification: A hands-on experience

Guidelines for radioiodine therapy in differentiated thyroid cancer and post-therapeutic follow-up

The use of vacuum fine needle aspiration biopsy of small formations in the diagnosis of thyroid cancer

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