Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus

Bragin, Denis E; Bragina, Olga; Monickaraj, Finny; Noghero, Alessio; Trofimov, Alex; Nemoto, Edwin M.; Kameneva, Marina V.

doi:10.1007/978-3-031-14190-4_53

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2024

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Cited by 2 publications

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The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside

Niu,

Xu,

Liu

et al. 2024

J Mol Histol

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The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside

Niu,

Xu,

Liu

et al. 2024

J Mol Histol

View full text Add to dashboard Cite

The GLCCI1/STAT3 pathway: A novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside

Niu,

Xu,

Liu

et al. 2024

Preprint

View full text Add to dashboard Cite

Diabetic cognitive dysfunction (DCD) is a complication of diabetes that seriously affects quality of life. Glucocorticoid-induced transcript 1 (GLCCI1) has been found to be involved in inflammation, apoptosis and autophagy in various diseases. However, the distribution of GLCCI1 in the brain and its role in DCD have not yet been revealed. In addition, the potential therapeutics effects of salidroside (SAL), a phenyl propyl glycoside compound known for its neuroprotective effects in treating DCD are unknow. In the present study, we found that GLCCI1 was localized in hippocampal neurons. C57BL/6J mice with DCD presented downregulation of GLCCI1 and Bcl-2 and upregulation of p-STAT3, Bax, Caspase-3 and Cleaved Caspase-3. Overexpression of GLCCI1 or SAL administration relieved DCD, reversed the changes in the expression of these cytokines, and alleviated morphological alterations in hippocampal neurons. Interestingly, SAL alleviated DCD and attenuated the expression of GLCCI1 and p-STAT3, showing similar effects as GLCCI1 overexpression. These findings suggest that the GLCCI1/STAT3 axis plays a crucial role in DCD and is involved in SAL-mediated attenuation of DCD.

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Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus

Cited by 2 publications

References 11 publications

The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside

The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside

The GLCCI1/STAT3 pathway: A novel pathway involved in diabetic cognitive dysfunction and the therapeutic effect of salidroside

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