Dragon's blood Croton palanostigma induces genotoxic effects in mice

Maistro, Edson Luis; Ganthous, Giulia; Machado, Marina da Silva; Zermiani, Tailyn; Andrade, Sérgio Faloni de; Rosa, Paulo; Perazzo, Fábio Ferreira

doi:10.1016/j.jep.2013.03.026

Cited by 7 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compagnone et al (2010) in their studies evaluated the in vitro the cytotoxicity of essential oil from leaves of C. matarensis against three different human cancer cell lines, colon adenocarcinoma, cervical carcinoma and fibroblasts, the results describe that, the CI50 assays obtained the respective values: 36.60, 83.90 and 132.73 μg/mL, these findings suggest regular cytotoxicity. Maistro et al (2013) conducted tests on mice to investigate the chemical components and to evaluate the toxic effect of the aqueous extract of Croton palanostigma, the tests concluded that the main chemical component taspine one alkaloid present in the crude sap showed genotoxic effects in liver cells, on this way, concluding that the sap should be used with caution. Shantabi et al (2020) using the ethanol extract of C. caudatus in tests with HeLa cells, with purpose to observe a toxicological response, concluding that the ethanol extract increases lipid peroxidation and the release of lactate dehydrogenase, relating cell death to the possibility of formation of free radicals, consequently increased DNA damage and cell apoptosis.…”

Section: Toxicitymentioning

confidence: 99%

Croton sp.: a review about Popular Uses, Biological Activities and Chemical Composition

Guerra

Ferreira

Oliveira

et al. 2022

RSD

View full text Add to dashboard Cite

The genus Croton, belonging to the Euphorbiaceae family, is a plant with shrubby characteristics, with the ability to regrow in times of rain, develops wildly, especially in deforestation areas, being reported mainly in the Caatinga and Forest region. One of the main characteristics of this genus is that several species are rich in chemical constituents of importance for medicine. In this way, this review of the literature, has an objective that findings regarding the biological activities and chemical composition of Croton species. This study is a literature review, carried out in the following databases: SciELO, BVS, MEDLINE, LILACS, PubMed and ScienceDirect, with a time frame between 1997 and 2020. The articles studied have shown different activities for Croton species, such as anti-inflammatory, antihypertensive, antifungal, antimicrobial, antidiabetic, antioxidant, antinociceptive and anti-tumor. Regarding toxicological aspects, the findings suggest caution in the use of Croton species, as some are toxic. While, regarding the chemical composition, in most species the presence of several secondary metabolites is observed, such as alkaloids, terpenoids, flavonoids and other phenolic compounds. Therefore, the results described in this article suggest that the therapeutic application of Croton species is supported by the literature, however we point out that caution is required in the use of Croton species, some present due to toxicity.

show abstract

Section: Toxicitymentioning

confidence: 99%