2021
DOI: 10.1111/ans.17296
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Drain fluid amylase and lipase as a predictive factor of postoperative pancreatic fistula

Abstract: Background: Early detection of a postoperative pancreatic fistula (POPF) may improve outcomes after pancreaticoduodenectomy (PD). The aim was to assess the role of postoperative drain fluid amylase (DFA) and lipase (DFL) measurements as a predictive indicator in the development of POPF. Methods: This retrospective cohort study included all PD procedures performed between 2009 and 2017 at Fremantle and Fiona Stanley Hospital in Western Australia. The DFA and DFL measurements on postoperative day (POD) three and… Show more

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Cited by 3 publications
(3 citation statements)
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“…Patients with amylase levels in drains ³971.50 U/L had significantly higher risks of POPF Grade C (RR: 31.43; 95% CI: 1.85-532.79; p =0.017), abdominal collections (RR: 31.43; 95% CI: 1.85-532.79; p =0.017), delayed gastric emptying (RR: 3.27; 95% CI: 1.94-5.53; p =0.000), readmission to hospital (RR: 54.29; 3.37-873.26; p =0.005), reoperation (RR: 48.57; 95% CI: 2.99-788.05; p =0.006), and mortality (RR: 60.00; 95% CI: 3.76-958.51; p =0.004) than patients with amylase levels in drains <971.50 U/L. Our results are consistent with similar results reported in several recent studies [ 9 , 25 - 28 ].…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…Patients with amylase levels in drains ³971.50 U/L had significantly higher risks of POPF Grade C (RR: 31.43; 95% CI: 1.85-532.79; p =0.017), abdominal collections (RR: 31.43; 95% CI: 1.85-532.79; p =0.017), delayed gastric emptying (RR: 3.27; 95% CI: 1.94-5.53; p =0.000), readmission to hospital (RR: 54.29; 3.37-873.26; p =0.005), reoperation (RR: 48.57; 95% CI: 2.99-788.05; p =0.006), and mortality (RR: 60.00; 95% CI: 3.76-958.51; p =0.004) than patients with amylase levels in drains <971.50 U/L. Our results are consistent with similar results reported in several recent studies [ 9 , 25 - 28 ].…”
Section: Discussionsupporting
confidence: 91%
“…The amylase level in drains on POD1 in patients with post-operative complications after Whipple resection was significantly higher than that in patients without complications (5052.22±2871.68 vs. 664.12±341.45 U/L, p<0.000). Patients with amylase levels in drains ³971.50 U/L had significantly higher risks of POPF Grade C (RR: 31.43; 95% CI: [9,[25][26][27][28].…”
Section: Discussionmentioning
confidence: 99%
“…Demographics, pre- and perioperative characteristics, and postoperative complications were recorded in a prospectively maintained database. POPFs were graded according to the ISGPF criteria [ 4 ], except lipase, which was measured instead of amylase at our institution [ 21 , 22 , 23 ]. The study was approved by the ethics committee of Ghent University Hospital (BC-08135) and performed according to the Declaration of Helsinki.…”
Section: Methodsmentioning
confidence: 99%