Dramatic decrease of circulating levels of monocyte chemoattractant protein-1 in Kawasaki disease after gamma globulin treatment

Terai, Masaru; Jibiki, Toshiaki; Harada, Akihisa; Terashima, Yuya; Yasukawa, Kumi; Tateno, Shigeru; Hamada, Hiromichi; Oana, Shinji; Niimi, Hiroo; Matsushima, Kouji

doi:10.1002/jlb.65.5.566

Cited by 50 publications

(56 citation statements)

References 48 publications

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“…Terai et al [11] observed that the early coronary lesions were infiltrated by large numbers of mononuclear cells, predominantly macrophages, implying the recruitment of monocytes from the circulation in response to chemotactic stimuli. In the literature, chemokines have been mentioned to play an important role in the pathogenesis of coronary artery disease (i.e.…”

Section: Discussionmentioning

confidence: 99%

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Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease

Breunis

Biezeveld

Geissler

et al. 2007

Clinical and Experimental Immunology

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SummaryKawasaki disease (KD) is an acute vasculitis occurring in young children. Its aetiology is unknown, but an infectious agent is assumed. Increased levels of proinflammatory cytokines and chemokines have been reported in KD. Genetic variation in these genes and the receptors for these genes could influence the regulation of cytokines and chemokines. In a case-control study of 170 Dutch Caucasian KD patients and 300 healthy Dutch Caucasian controls, common genetic variants in chemokine receptor genes CCR3, CCR2, CCR5, CX3CR1, CXCR1 and CXCR2 were analysed. Of the eight studied single nucleotide polymorphisms (SNPs) in the CCR3-CCR2-CCR5 gene cluster, four showed a significant association with susceptibility to KD. Moreover the CCR5-D32 was observed with an allele frequency of 10·7% in the control population compared to 6·5% in the KD patients (P = 0·04). Two haplotypes of the CCR3-CCR2-CCR5 gene-cluster appear to be at risk haplotypes for KD and one a protective haplotype. No association was observed with the studied SNPs in CX3CR1, CXCR1 and CXCR2. In conclusion, in a Dutch cohort of KD patients an association of KD occurrence with common genetic variants in the chemokine receptor gene-cluster CCR3-CCR2-CCR5 was observed.

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Section: Discussionmentioning

confidence: 99%

“…In children with KD, increased levels of proinflammatory cytokines [interleukin (IL)-6, tumour necrosis factor (TNF)-a] [5][6][7][8] and chemokines [IL-8, monocyte chemoattractant protein (MCP)-1, regulated upon activation normal T cell expressed and secreted (RANTES)] have been reported [9][10][11]. Genetic variations, i.e.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease

Breunis

Biezeveld

Geissler

et al. 2007

Clinical and Experimental Immunology

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“…Earlier studies (5)(6)(7)(8)10) on the production or expression of chemokines in Kawasaki disease have focused mainly on CC chemokines or IL-8. Moreover, a leptin study of Kawasaki disease has not been performed yet.…”

Section: Discussionmentioning

confidence: 99%

“…There have been various studies of IL-8 modulation with IVIG in Kawasaki diseases (8,10,26). In a study by Asano et al (26), the expression of IL-8 was shown to increase after IVIG, and Terai et al (7) have reported that IVIG treatment correlated with a rapid decrease in the circulating levels of MCP-1 but not IL-8. In an In vitro study with human monocyte (27), IVIG has also been shown to enhance the expression of IL-8 mRNA and protein production.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies (2)(3)(4)(5) suggest that cytokines play an important role in the onset of this disease. Recently, several studies (6)(7)(8)(9)(10) have been concerned about chemokines, a large family of structurally related small proteins of 8～10 kDa sharing the ability to induce chemotaxis and tissue extravasation and to modulate various functions of leukocytes. Chemokines (11) are important for the recruitment of leukocytes to sites of infection, which is essential in host defense and may lead to clearance of inciting factors, and have been detected in body fluids and tissues in a variety of pathologic conditions.…”

Section: Introductionmentioning

confidence: 99%

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Production of Plasma Leptin and Expression of Interferon-γ Inducible Protein-10 (IP-10), Monokine Induced by Interferon-γ (Mig) and Interleukin-8 (IL-8) mRNA in Kawasaki Disease

Lee

Kim

2002

Immune Netw

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Background: Kawasaki disease is an acute febrile illness with systemic vasculitis which primarily affects children, We examined the production of leptin in plasma and gene expressions of CXC chemokines in peripheral blood mononuclear cells from patients with Kawasaki disease. Methods: Consecutive 39 samples from 13 patients according to the different clinical stages (acute, subacute, convalescent) of Kawasaki disease were collected. The plasma leptin levels according to clinical stages of Kawasaki disease were examined by ELISA and the expression of IP-10, Mig and IL-8 mRNAs in 39 samples (13 samples of each stage) from 13 cases were examined by RT-PCR. Results: There were not significant changes of plasma leptin levels according to the clinical stages of Kawasaki disease. The mean values of plasma leptin concentrations during each of the stages (n=13, p＞0.05, pg/ml) were 335.8±549.0 in acute, 358±347.6 in subacute, and 443.6±645.9 in convalescent stage. The mRNAs of IP-10, Mig, and IL-8 were expressed in 13/13 (100%), 2/13 (15%), 9/13 (69%) during acute stage, 13/13 (100%), 6/13 (46%), 13/13 (100%) during subacute stage, and 13/13 (100%), 4/13 (31%), 10/13 (77%) during the convalescent stage, respectively. In three patients, the production of leptin and expression of IP-10 mRNA were dramatically decreased according to the process of the clinical stages. In five patients with prominent cervical lymphadenopathy, the expression of IL-8 mRNA during the subacute stage was more elevated than the acute and convalescent stages. Conclusion: This data suggests that the production of leptin and the gene expressions of IP-10, Mig and IL-8 seem to have no significant correlation to the clinical stages of Kawasaki disease. However, expression patterns of IP-10, Mig and IL-8 mRNA may be related to the specific clinical manifestations, and the expression of IP-10 may also be correlated to leptin levels with pericardial involvement.

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Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease

Jibiki

Terai

Shima

et al. 2001

Arthritis & Rheumatism

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Dramatic decrease of circulating levels of monocyte chemoattractant protein-1 in Kawasaki disease after gamma globulin treatment

Cited by 50 publications

References 48 publications

Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease

Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease

Production of Plasma Leptin and Expression of Interferon-γ Inducible Protein-10 (IP-10), Monokine Induced by Interferon-γ (Mig) and Interleukin-8 (IL-8) mRNA in Kawasaki Disease

Monocyte chemoattractant protein 1 gene regulatory region polymorphism and serum levels of monocyte chemoattractant protein 1 in Japanese patients with Kawasaki disease

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