Dramatic effect of hydroxychloroquine on lupus alopecia

Igari, Shohei; Yamamoto, Toshiyuki

doi:10.1111/1346-8138.14069

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…In case reports, treatment with HCQ as monotherapy or in combination with other treatments resulted in improvement in alopecia secondary to variants of CLE, including DLE, LEP, and tumid LE. 12,20,28,30,44,[57][58][59] It is important to note that HCQ above a dose regimen of 5 mg/kg is associated with significant ocular toxicity and should be avoided. 60…”

Section: Corticosteroids and Antimalarialsmentioning

confidence: 99%

Recent Insight on the Management of Lupus Erythematosus Alopecia

Desai¹,

Miteva²

2021

CCID

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Lupus erythematosus (LE) is a chronic autoimmune condition with a wide spectrum of clinical presentations. Alopecias, both non-scarring and scarring, frequently occur in the context of LE and can assume several different patterns. Furthermore, alopecia occurring with LE may be considered LE-specific if LE-specific features are present on histology; otherwise, alopecia is considered non-LE-specific. Non-scarring alopecia is highly specific to systemic LE (SLE), and therefore has been regarded as a criterion for the diagnosis of SLE. Variants of cutaneous LE (CLE), including acute, subacute, and chronic forms, are also capable of causing hair loss, and chronic CLE is an important cause of primary cicatricial alopecia. Other types of hair loss not specific to LE, including telogen effluvium, alopecia areata, and anagen effluvium, may also occur in a patient with lupus. Lupus alopecia may be difficult to treat, particularly in cases that have progressed to scarring. The article summarizes the types of lupus alopecia and recent insight regarding their management. Data regarding the management of lupus alopecia are sparse and limited to case reports, and therefore, many studies including in this review report the efficacy of treatments on CLE as a broader entity. In general, for patients with non-scarring alopecia in SLE, management is aimed at controlling SLE activity with subsequent hair regrowth. Topical medications can be used to expedite recovery. Prompt treatment is crucial in the case of chronic CLE due to potential for scarring and irreversible damage. First-line therapies for CLE include topical corticosteroids and oral antimalarials, with or without oral corticosteroids as bridging therapy. Second and third-line systemic treatments for CLE include methotrexate, retinoids, dapsone, mycophenolate mofetil, and mycophenolate acid. Additional topical and systemic medications as well as physical modalities used for the treatment of lupus alopecia and CLE are discussed herein.

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Section: Corticosteroids and Antimalarialsmentioning

confidence: 99%

Recent Insight on the Management of Lupus Erythematosus Alopecia

Desai¹,

Miteva²

2021

CCID

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“…Hamilton et al 7 treated DLE‐induced hair loss by oral administration of prednisone, hydroxychloroquine; topical use of clobetasol and tacrolimus; and local injection of triamcinolone to achieve hair regeneration. A patient with hair loss diagnosed with DLE showed a reduction in skin lesions after treatment with a small dose of hydroxychloroquine (200 mg/day) and also had new hair appearing in the alopecia area 8 . Yokogawa et al 9 confirmed in a double‐blind, randomized controlled trial that hydroxychloroquine remarkably improved the clinical symptoms of patients compared with placebo.…”

Section: Discussionmentioning

confidence: 99%

Innovative use of concentrated growth factors combined with corticosteroids to treat discoid lupus erythematosus alopecia: A case report

Fang

Liu

Cheng

et al. 2021

J of Cosmetic Dermatology

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Alopecia for patients with discoid lupus erythematosus can sometimes be a refractory condition, where mixed infiltrates of T lymphocytes and histiocytes leads to destruction of hair follicles, which might cause permanent scarring. Early diagnosis and timely treatment can achieve hair regeneration and prevent further disease progression. Concentrated growth factor, a novel autologous plasma extract, contains various growth factors that could promote tissue regeneration. In this article, we report a case of cell growth factor combined with corticosteroids for the treatment of discoid lupus erythematosus alopecia. This case study concludes with satisfactory clinical effect.

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“…CA from CCLE is seven times more common in women. CA is generally permanent and irreversible, 2 although hair regrowth has been noted in some patients with CA secondary to CCLE 3‐5 . We present three cases of CCLE where prompt treatment led to significant hair regrowth.…”

Section: Figurementioning

confidence: 90%