Dramatic Increase of Multiresistant Microorganisms

Abstract

For people in the 21st century, it is hard to imagine the world before antibiotics. At the beginning of the 20th century, as many as nine women out of every 1,000 who gave birth died, 40 percent from sepsis. In some cities as many as 30 percent of children died before their first birthday. One of every nine people who developed a serious skin infection died, even from something as simple as a scrape or an insect bite. Pneumonia killed 30 percent of those who contracted it; bacterial meningitis was almost universally fatal. Ear infections caused deafness; sore throats were not infrequently followed by rheumatic fever and heart failure. Surgical procedures were associated with high morbidity and mortality due to infection. This picture changed dramatically with three major developments: improvements in public health, vaccines, and antibiotics. Over the course of the 20 th century, deaths from infectious diseases declined markedly and contributed to a substantial increase in life expectancy. Antibiotics, in particular, have saved millions of lives. But the world is now at dire risk of losing this progress. Bacteria and other microbes evolve in response to their environment and inevitably develop mechanisms to resist being killed by antibiotics but also disinfectants [1,2]. For many decades, the problem was manageable as the growth of resistance was slow and the pharmaceutical industry continued to create new antibiotics. Over the past decade, however, this brewing problem has become a crisis. The evolution of antibiotic resistance is now occurring at an alarming rate and is outpacing the development of new countermeasures capable of thwarting infections in humans [3]. This situation threatens patient care, economic growth, public health, agriculture, economic security, and national security. The UN Interagency Coordination Group on Antimicrobial Resistance demands therefore immediate, coordinate and ambitious measures to combat this problem [4].

Worldwide Distribution of Pathogens by Public Transport can be Prevented by In Situ Generated Biocides

“…Disinfection of surfaces with disinfectants is not constructive any more as ample evidence exists for tolerance of microorganisms to sublethal levels of various disinfectants e.g quaternary ammonium compounds (QAC) i.e. benzalkonium chloride as well as chlorhexidine, hexadecyl pyridinium and cetrimide [51]. The resistance of QAC based disinfectants to antibiotics is conferred by the resistance determinants qacH and bcrABC.…”

"Transmission of Covid 19 From Contaminated Surfaces"

“…Investigation by the push plate method (RODAC Plate method) is therefore much more meaningful. The antimicrobial activity of technologies based only on formation of free oxygen radicals cannot be documented by the push plate (RODAC plate Replicate Organism Detection and Counting) method which is relevant for germfree surfaces [12,13].…”

Let’s evaluate the pandemic in terms of facts, not impressions

“…So far, this is only a postulate that is waiting for confirmation, but objective data on the transformation of the accompanying microflora that arose as a result of this type of therapy are one of the proofs of the changes that have already occurred. 46,47 In the end, we must agree with the assessment of modern care for patients with COVID-19 pneumonia, which is given by I. Zagury-Orly and R.M. Schwartzstein, that "Physicians are treating patients, with unsparing generosity..." and the cause of therapeutic errors is "cognitive biases".…”