Drawing tubular fibres: experiments versus mathematical modelling

Chen, Michael; Stokes, Yvonne M.; Buchak, Peter; Crowdy, Darren; Foo, Herbert Tze Cheung; Dowler, Alastair; Ebendorff-Heidepriem, Heike

doi:10.1364/ome.6.000166

Cited by 23 publications

(18 citation statements)

References 18 publications

(56 reference statements)

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“…A key aspect of these results to note is that, as calculated from the assumed temperature/viscosity profile (11)- (12), this experiment was performed at relatively high tension, as compared to the experiments reported in [10], for instance. The pressures applied to the holes are also orders of magnitude larger than in that work.…”

Section: Resultsmentioning

confidence: 95%

“…As demonstrated by [3], making any such assumption about the unknown temperature profile can be avoided by measuring fibre tension during a draw. Further modelling of this profile is crucial if it is to be fully understood, since it is clear from the experiments on tubular drawing in [10] that it depends on both peak furnace temperature and the geometry of the internal channels over the neck-down region. Future efforts will concentrate on modelling this axially varying temperature; it may be possible to develop a model for drawing MOFs by extending previous studies of simpler geometries, for instance the asymptotic approaches to the temperature modelling of solid fibre drawing [15] or the stretching of heated tubes [16].…”

Section: Discussionmentioning

confidence: 99%

“…In our previous experimental study [10] we measured fibre tension directly, but did not impose a specific viscosity profile in the model. This meant the model output consisted of the final geometry of the fibre and the dimensionless parameter γ * , from which the harmonic mean of viscosity could be inferred via (3).…”

Section: Asymptotic Modelling Approachmentioning

confidence: 99%

“…The model has already been validated against experiments where tubular preforms were drawn to fibre under a range of conditions [10] and was generally an excellent match for these simple geometries. Other studies have similarly demonstrated the utility of asymptotic models for drawing tubular fibres [11], [12] and for multi-holed geometries with channels separated by thin struts [13].…”

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Asymptotic Modelling of a Six-Hole MOF

Chen

Stokes

Buchak

et al. 2016

J. Lightwave Technol.

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Abstract-We model the drawing of a six-hole microstructured optical fibre with a combination of asymptotic techniques and a new efficient numerical method, and compare this to a previous set of experiments and finite element simulations. The new approach accurately models the deformation of the inner channels and predicts cross-sectional fibre geometries which are a better match to the experiments than the previous, more computationally expensive simulation technique.

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Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Asymptotic Modelling Approachmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Asymptotic Modelling of a Six-Hole MOF

Chen

Stokes

Buchak

et al. 2016

J. Lightwave Technol.

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“…When pulling micropipettes, capillaries with slightly different IDs and ODs will have different distances to the box heating filament and different volume of air enclosed in the internal channel, which can alter the glass temperature and result in variations in tip ID and OD of micropipettes. 36 In addition, this effect is enlarged due to the inherent fluctuations of heating temperature, air pressure and moisture, and capillary emplacement in the puller, though model P-97 is designed with good reproducibility. Moreover, the reliability of each puller is different and largely dependent on its fine settings.…”

Section: Optimizing the Tip Size Of Micropipette For Intracellular Dementioning

confidence: 99%

Intracellular Delivery of NanoparticlesviaMicroelectrophoresis Technique: Feasibility demonstration

Han

Zhao

Fabian

et al. 2020

Preprint

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Nanoparticles with desirable properties and functions have been actively developed for various biomedical research, such as in vivo and in vitro sensors, imaging agents and delivery vehicles of therapeutics. However, an effective method to deliver nanoparticles into the intracellular environment is a major challenge and critical to many biological studies. Current techniques, such as intracellular uptake, electroporation and microinjection, each have their own set of benefits and associated limitations (e.g., aggregation and endosomal degradation of nanoparticles, high cell mortality and low throughput). Here, the well-established microelectrophoresis technique is applied for the first time to deliver nanoparticles into target cells, which overcomes some of these delivery difficulties. Semiconductive quantum dots, with average hydrodynamic diameter of 24.4 nm, have been successfully ejected via small electrical currents (-0.2 nA) through fine-tipped glass micropipettes as an example, into living human embryonic kidney cells (roughly 20 -30 µm in length). As proposed by previous studies, micropipettes were fabricated to have an average tip inner diameter of 206 nm for ejection but less than 500 nm to minimize the cell membrane damage and cell distortion. In addition, delivered quantum dots were found to stay monodispersed within the cells for approximately one hour. We believe that microelectrophoresis technique may serve as a simple and general strategy for delivering a variety of nanoparticles intracellularly in various biological systems.

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Cytoplasmic delivery of quantum dots via microelectrophoresis technique

et al. 2021

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Nanoparticles with specific properties and functions have been developed for various biomedical research applications, such as in vivo and in vitro sensors, imaging agents and delivery vehicles of therapeutics. The development of an effective delivery method of nanoparticles into the intracellular environment is challenging and success in this endeavor would be beneficial to many biological studies. Here, the well‐established microelectrophoresis technique was applied for the first time to deliver nanoparticles into living cells. An optimal protocol was explored to prepare semiconductive quantum dots suspensions having high monodispersity with average hydrodynamic diameter of 13.2–35.0 nm. Micropipettes were fabricated to have inner tip diameters of approximately 200 nm that are larger than quantum dots for ejection but less than 500 nm to minimize damage to the cell membrane. We demonstrated the successful delivery of quantum dots via small electrical currents (–0.2 nA) through micropipettes into the cytoplasm of living human embryonic kidney cells (roughly 20–30 μm in length) using microelectrophoresis technique. This method is promising as a simple and general strategy for delivering a variety of nanoparticles into the cellular environment.

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Drawing tubular fibres: experiments versus mathematical modelling

Cited by 23 publications

References 18 publications

Asymptotic Modelling of a Six-Hole MOF

Asymptotic Modelling of a Six-Hole MOF

Intracellular Delivery of NanoparticlesviaMicroelectrophoresis Technique: Feasibility demonstration

Cytoplasmic delivery of quantum dots via microelectrophoresis technique

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