Let M C = A C 0 B be a 2 × 2 upper triangular operator matrix acting on the Hilbert space H ⊕ K. In this paper, for given operators A and B, we prove thatthe Browder resolvent of an operator T and C∈B(K,H) σ (M C ) has been determined in [H.K. Du, P. Jin, Perturbation of spectrums of 2 × 2 operator matrices, Proc. Amer. Math. Soc. 121 (1994) 761-776]. Moreover, we explore the relations of σ (A) ∪ σ (B) \ σ (M C ), σ b (A) ∪ σ b (B) \ σ b (M C ) and σ w (A) ∪ σ w (B) \ σ w (M C ), where σ (A), σ b (A) and σ w (A) denote the spectrum, the Browder spectrum and the Weyl spectrum of A, respectively.