Dreadful Consequences of Sarcopenia and Osteoporosis due to COVID-19 Containment

Current Data on Lower Prevalence and Age-Related Aggravation of COVID-19 in Japan

“…Furthermore, several cohort studies showed several risks related to the aggravation of COVID-19 [3]. They include the influence of obesity, sarcopenia and so on [4,5]. Such factors and international comparison would be considered for the management of COVID-19 [6].…”

“…What kind of risk factors are involved in the aggravation of clinical progress? The influencing factors are advancing age, underlying pathologies such as obesity, chronic obstructive pulmonary disease (COPD), chronic kidney disease (CKD), diabetes mellitus (DM), hypertension, atherosclerotic cardiovascular disease (ASCVD), obesity, smoking, inactivity and so on [4,5,11,12].…”

Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A Minireview

“…The findings from these studies strongly indicate that the Trp-Kyn pathway is altered in COVID-19 patients, leading to a decrease in Trp levels and an increase in Kyn and its metabolites. Recent studies also demonstrated reduced muscle mass and bone loss in COVID-19 patients [ 17 – 20 ]. Based on the findings from our group and published literature, we came up with a novel perspective suggesting that the activation of the Trp-Kyn pathway in COVID-19 patients might be involved in bone and muscle loss.…”

COVID-19 pandemic: a wake-up call for lifestyle-related preventable conditions in older adults

“…Hypertension, diabetes, and cardiovascular and cerebrovascular diseases are the most prevalent conditions associated with increased severity and mortality in COVID-19 patients, as well as advancing age, excessive body mass index (BMI), frailty, and various other chronic conditions. The elderly population in particular is likely to worsen their underlying debilitating conditions during the ongoing pandemic, making them more prone to both infectious and non-communicable conditions [ 2 ]. Considering the susceptibility of these individuals, routine follow-up and modification of current treatment might be interrupted or even postponed indefinitely during the current pandemic, increasing the burden of already overwhelmed medical workers.…”

“…Hence, in the near future, the wave of non-communicable diseases and frailty conditions (e.g. osteoporosis, sarcopenia) may appear inevitable without appropriate intervention of public health authorities around the world [ 1 , 2 ]. This is a wake-up call to create a more sustainable approach to help individuals, especially older people, practicing physically active lifestyle.…”