Dresdner Nabelschnurblutbank - Erfahrungen der Nabelschnurblutbank in Dresden, unterstützt durch die Deutsche Knochenmarkspenderdatei -

Ordemann, R; Petzold, Kathrin; Hölig, Kristina; Schaffer, B; Freude, M; Mauersberger, Sabine; Ehninger, G.

doi:10.1055/s-2000-8492

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Damit sind neonatale Stammzellen in gleicher Weise einsetzbar wie die hämatopoetischen Stammzellen aus dem Knochenmark und dem peripheren Blut. Gegenüber diesen weisen neonatale Stammzellen jedoch einige Vorteile auf [1,2,5,6,7,10,11,12,13,14] [1,4,5,6,7,9,10].…”

Section: Introductionunclassified

“…Seit der ersten erfolgreichen Nabelschnurbluttransfusion im Jahre 1988 wurden bislang weltweit über 1.500 Patienten mit neonatalen Stammzellen behandelt. Dabei hat sich diese Therapie vor allem bei Kindern als viel versprechende Alternative zur Therapie mit adulten Stammzellen aus dem Knochenmark oder aus dem peripheren Blut erwiesen [1,2,3,4]. Da das Nabelschnurblut neben hämatopoetischen Stammzellen möglicherweise auch solche enthält, die z.…”

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Neonatale Stammzellen

Dohmen

2004

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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With regard to the great social importance and ethical acceptance of cord blood stem cell research, this article is devoted to basic legal questions concerning the use of umbilical cord blood. The original legal status of the cord blood was analyzed with the result that the cord blood belongs to the child, and thus the child can claim certain personal rights regarding the cord blood. Since the newborn itself is not able to take part in legal transactions, its parents have to ensure that its personal and financial concerns are protected, as they are its legal representatives. The parents can decide together what shall happen to the cord blood because of their parental custody. They have to give their consent to the donation of the cord blood as well as to the collection of personal data of the child. The duty to obtain permission for the production of stem cell preparations derives from the German drug law. Maternity clinics and cord blood banks need this permission and those blood banks that stock up on cord blood stem cell preparations for indefinite recipients have to obtain an additional authorization because these preparations are prefabricated drugs.

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Section: Introductionunclassified

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Neonatale Stammzellen

Dohmen

2004

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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Analysis of the French National Registry of unrelated bone marrow donors, using surnames as a tool for improving geographical localisation of HLA haplotypes

2003

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The first statistical analysis of the French National Registry of volunteer bone marrow donors estimated the probabilities of haplotype frequencies separately for each of the 20 administrative regions of France. Here we propose to use donors' surnames to increase the accuracy of location of the donor's geographical origin. This approach allows us to estimate haplotype frequencies for administrative entities (90 departments) smaller than regions and to correct for bias resulting from recent mobility. We analysed 30 777 donors typed for HLA-A,B and 17 745 donors typed for HLA-A,B,DR,DQ. By using the donors' surnames, we identified common and rare haplotypes (those found in only one department) and estimated the degree of HLA polymorphism at the department level. We also identified departments with a distinctive genetic structure (for example, Paris, Corsica, Pyrenees and Meurthe-et-Moselle). By providing a more accurate geographical distribution of HLA polymorphisms in France, this study will enable us to optimise policies for recruiting bone marrow donors and to improve the fit between the donor file and patients' needs.

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Dresdner Nabelschnurblutbank - Erfahrungen der Nabelschnurblutbank in Dresden, unterstützt durch die Deutsche Knochenmarkspenderdatei -

Cited by 2 publications

References 11 publications

Neonatale Stammzellen

Neonatale Stammzellen

Analysis of the French National Registry of unrelated bone marrow donors, using surnames as a tool for improving geographical localisation of HLA haplotypes

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