DRESS syndrome

Husain, Zain; Reddy, Bobby Y.; Schwartz, Robert A.

doi:10.1016/j.jaad.2013.01.033

Cited by 386 publications

(232 citation statements)

References 110 publications

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“…DRESS syndrome is characterized by a latency of 2 weeks to 3 months between exposure to the drug and the development of the condition, with a lengthy recovery process despite drug discontinuation 7,9,10 .…”

Section: Discussionmentioning

confidence: 99%

“…It was also found to be associated with reactivation of other herpes viruses, including herpes virus 7, Epstein-Barr virus and cytomegalovirus 6 . On the other hand, relationships have been established between certain HLA haplotypes and a predisposition to develop DRESS syndrome with some drugs, and specific mutations have been described in genes that code for detoxifying enzymes 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Support measures and fluid/electrolyte balance should be implemented in cases of extensive cutaneous involvement. The most widely accepted treatment is systemic corticosteroids for an extended period and with a gradual decrease to avoid relapses 15 . However, other treatment regimens, such as the use of topical corticosteroids, have been proposed in mild to moderate cases without systemic involvement.…”

Section: Tabla 2 Criterios Diagnósticos J-scar Para Síndrome Dressmentioning

confidence: 99%

“…Initially, the condition was referred to as anticonvulsant hypersensitivity syndrome, due to its occurrence in relation to the use of these drugs; however, the diagnosis was extended to DRESS, since many other medications have been implicated 7,8 .…”

Section: Introductionmentioning

confidence: 99%

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Síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos en pediatría. Caso clínico

Silva-Feistner

Ortiz

Rojas-Lechuga

et al. 2016

Revista Chilena de Pediatría

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Introduction: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially lifethreatening, drug-induced hypersensitivity reaction that includes skin eruptions, fever, lymphadenopathy, hematological abnormalities, and internal organ involvement. Objective: To present a rare condition in children; to facilitate a rapid diagnostic suspicion and recognition by doctors. Case report: A 9 months old infant admitted due to a severe viral pneumonia, treated with non-invasive ventilation and ceftriaxone, among other medications. Five days after stopping antibiotics, a violetcolored maculopapular rash appeared, confluent predominantly in the trunk, face and upper extremities, combined with a fever, eosinophilia, and elevated transaminases. She was treated with oral prednisone and topical corticosteroids for 6 weeks, with good results at 3 months follow-up. Conclusions: The diagnosis of DRESS syndrome is made using clinical criteria and laboratory examinations, as well as a skin biopsy in the case of any doubt in the diagnostics. Although it is most frequently caused by anticonvulsants, many other drugs have been implicated. Management consists of discontinuing the suspected drug associated with the reactions and a prolonged treatment of corticosteroids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Tabla 2 Criterios Diagnósticos J-scar Para Síndrome Dressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos en pediatría. Caso clínico

Silva-Feistner

Ortiz

Rojas-Lechuga

et al. 2016

Revista Chilena de Pediatría

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“…There are no Reed-Sternberg cells or capsular invasion. This pseudolymphoma pattern can be difficult to distinguish from that of a true lymphoma (6). Nevertheless, multicentric Castleman disease (MCD), IgG4-related diseases (IgG4-RD) and DILE share many clinical and laboratory findings with DRESS syndrome.…”

Section: Discussionmentioning

confidence: 99%

Late-onset Anticonvulsant Hypersensitivity Syndrome Mimicking Lymphoma

et al. 2015

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Anticonvulsant hypersensitivity syndrome is a fatal, idiosyncratic drug reaction that is caused by aromatic antiepileptic drugs. This cutaneous drug reaction is also called pseudolymphoma because of its clinical and histological similarities with malignant lymphoma. The primary clinical findings are fever, skin rashes, enlarged lymph nodes, single or multiple internal organ involvement and hematological abnormalities. Typically, anticonvulsant hypersensitivity syndrome occurs 1-8 weeks after drug administration. We herein present the case of a patient who had been on anticonvulsant therapy for five years and died from late-onset anticonvulsant hypersensitivity syndrome.

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Cyclosporine Treatment of Drug-Induced Hypersensitivity Syndrome

2016

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rug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, is a rare, potentially life-threatening adverse reaction to medication. The diagnosis of DIHS is based on clinical and biochemical findings. It commonly presents clinically with fever, facial swelling, lymphadenopathy, and a morbilliform eruption. 1 Internal organ involvement can include hepatic, renal, pulmonary, hematologic, cardiac, and endocrine abnormalities. 1 Most often, DIHS is caused by anticonvulsants, antibiotics, and allopurinol. 2 With an estimated mortality rate up to 10%, the treatment of DIHS is important. 3 Treatment of DIHS involves withdrawal of treatment with the suspected causative medication, supportive care, and often systemic corticosteroids. In this observational case series, 2 patients referred to the der-matology service of an academic tertiary care hospital and subsequently diagnosed as having DIHS were studied from December 1, 2013, through July 31, 2014. These 2 patients were treated with a short course of cyclosporine followed by a quick resolution of the adverse drug reaction. The findings suggest that cyclosporine is a potential alternative to the traditional long course of systemic corticosteroids in the treatment of DIHS.

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DRESS syndrome

Cited by 386 publications

References 110 publications

Síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos en pediatría. Caso clínico

Síndrome de sensibilidad a fármacos con eosinofilia y síntomas sistémicos en pediatría. Caso clínico

Late-onset Anticonvulsant Hypersensitivity Syndrome Mimicking Lymphoma

Cyclosporine Treatment of Drug-Induced Hypersensitivity Syndrome

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