DRESS syndrome aux antituberculeux

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first‐line antituberculosis drugs: Two case reports and a review of the literature

“…Rifampicin and isoniazid appear to be the most frequently involved molecules, having been identified as the culprit agent in 19 cases (our case 1, and 18 cases in Supporting Information Table S1 3,6-12 and 18 cases (our cases 1 and 2, and 16 cases in Supporting Information Table S1, 3,[6][7][8]11,[13][14][15][16][17][18] respectively. This equally applies to tuberculosis patients concomitantly infected with human immunodeficiency virus (HIV).…”

“…This equally applies to tuberculosis patients concomitantly infected with human immunodeficiency virus (HIV) . Pyrazinamide and ethambutol seem to be less frequently involved: pyrazinamide was implicated in 11 cases (ie, the two present clinical reports, as well as in nine cases in Supporting Information Table S1 . The only two cases in which pyrazinamide was successfully rechallenged are reported in References (Supporting Information Table S1).…”

“…19 Pyrazinamide and ethambutol seem to be less frequently involved: pyrazinamide was implicated in 11 cases (ie, the two present clinical reports, as well as in nine cases in Supporting Information Table S1. 3,[6][7][8][9]11,13,20 The only two cases in which pyrazinamide was successfully rechallenged are reported in References 10,17 (Supporting Information Table S1). Ethambutol produced a positive skin test reaction in only three cases (our case 1, and two cases in Supporting Information Table S1 14,21 ), gave a negative skin test result in two patients (Supporting Information Table S1), 7,18 and was responsible for a doubtful skin test result in our case 2.…”

“…Ethambutol produced a positive skin test reaction in only three cases (our case 1, and two cases in Supporting Information Table S1 14,21 ), gave a negative skin test result in two patients (Supporting Information Table S1), 7,18 and was responsible for a doubtful skin test result in our case 2. Ten other patients showed reactions when rechallenged with ethambutol (Supporting Information Table S1 [6][7][8][10][11][12][13]16 ). When ethambutol is implicated, it is usually responsible for the drug reaction together with one or more other first-line antituberculosis drugs.…”

DRESS syndrome à la phénytoïne

“…Les médicaments le plus souvent imputables sont les antiépileptiques (phénytoïne, valproate de sodium, lamotrigine, phénobarbital, carbamazépine), l'allopurinol et les antirétroviraux (Efanvirenz W ) [5]. Plus rarement ont été rapportés les antibiotiques, les anti-inflammatoires non stéroïdiens, l'oméprazole et plus récemment les antituberculeux [6]. La physiopathologie du DRESS syndrome s'est dernièrement éclairée par la mise en évidence de réactivation de virus du groupe Herpes : human Herpes virus 6 (HHV-6), cytomégalovirus (CMV), Epstein-Barr virus (EBV), human Herpes virus 7 (HHV-7).…”