DRESS syndrome sous doxycycline

Mailhol, C.; Tremeau-Martinage, C.; Paul, C.; Godel, A.; Lamant, Laurence; Giordano‐Labadie, F.

doi:10.1016/j.annder.2009.10.180

Cited by 13 publications

(5 citation statements)

References 12 publications

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“…In addition, several serious doxycycline-induced adverse reactions, such as pseudotumor cerebri and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, have emerged over the last few years. Although discontinuation of the medication yielded improvement in most reported cases, a few patients suffered from a permanent loss of visual acuity or loss of visual field 18 19 20 21 .…”

Section: Discussionmentioning

confidence: 97%

Comparison of the Efficacy of Azithromycin Versus Doxycycline in Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials

et al. 2018

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BackgroundAcne vulgaris is one of the most common disorders of the pilosebaceous unit. Although doxycycline is considered to be a first-line anti-acne antibiotic, various other antibiotics have been tried due to its adverse effects and contraindications. We performed a meta-analysis of randomized controlled trials (RCTs) that compared the efficacy of oral azithromycin pulse therapy with that of oral daily doxycycline in the management of moderate to severe acne vulgaris.MethodsFive scientific databases (MEDLINE, EMBASE, Cochrane Library, SCOPUS, and Web of Science) were searched to identify relevant studies. A review of 1,341 publications produced six RCTs that met our predefined inclusion criteria. The clinical outcome measures were remaining acne lesion counts, patients' self-assessment of treatment, and the investigators' assessment of treatment after 12 weeks.ResultsWe included six studies assessing 906 patients with moderate to severe acne vulgaris. Meta-analyses of clinical outcome measures revealed no significant difference between the two groups regarding remaining acne lesion counts (p=0.27), patients' self-assessment of treatment (p=0.67), and the investigators' assessment of treatment (p=0.32). The incidence of severe adverse events leading to the discontinuation of therapy was higher in the doxycycline daily therapy group when compared with the azithromycin pulse therapy group.ConclusionThis study indicates that azithromycin pulse therapy is equivalent to doxycycline at 12 weeks in the efficacy of the treatment for moderate to severe acne vulgaris Therefore, oral azithromycin pulse therapy may be a good alternative to doxycycline in the management of acne for those unable to tolerate doxycycline.

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Section: Discussionmentioning

confidence: 97%

Comparison of the Efficacy of Azithromycin Versus Doxycycline in Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials

et al. 2018

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“…There were 21 cases of tetracycline-induced DRESS (8.27% of antibiotic-induced DRESS cases) which most of them are related to minocycline, with long latency period in most of the cases (mean latency period of 28.48 days). Despite general safety records, doxycycline has been reported to have caused side effects, such as pseudotumor cerebri, AGEP, DRESS, and also Stevens-Johnson syndrome [ 60 ]. Just two cases of doxycycline-induced DRESS are reported to the best of our knowledge.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Sharifzadeh

Mohammadpour

Tavanaee

et al. 2020

Eur J Clin Pharmacol

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Background Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially lifethreatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this review, we try to summarize reports of antibacterial antibiotic-induced DRESS focusing on characteristics of DRESS induced by each antibiotic group. Methods The data were collected by searching PubMed/MEDLINE and ScienceDirect. The keywords used as search terms were "DRESS syndrome," "drug-induced hypersensitivity syndrome (DIHS)," "antibiotics," "antimicrobial," and names of various antimicrobial groups. Finally, 254 relevant cases with a definite or probable diagnosis of DRESS based on RegiSCAR criteria were found until 30 May 2020 and reviewed. Results and conclusion Totally, 254 cases of antibacterial antibiotic-induced DRESS are reported. Most of them are related to antituberculosis drugs, vancomycin, and sulfonamides, respectively. Rash and fever were most frequent clinical findings. Eosinophilia and liver injury were the most reported hematologic and visceral organ involvement, respectively. Most of the patients are managed with systemic corticosteroids. The death occurred in 16 patients which most of them experienced liver or lung involvement. The reactivation of various viruses especially HHV-6 is reported in 33 cases. The mean latency period was 29 days. It is necessary to perform thorough epidemiological, genetic, and immunological studies, also systematic case review and causality assessment, as well as well-designed clinical trials for better management of antibiotic-induced DRESS.

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“…4 Finally, at least three reported cases of DRESS syndrome following treatment with doxycycline exist, but no reports of seroconversion induced by doxycycline have been found. 5,6 In our patient, the onset of symptoms recurred shortly after reinitiating doxycycline. Although the original manifestations of her symptoms were highly suspected to be due to treatment with doxycycline, they could not have been confirmed given that other investigations, such as an EBV test, were positive.…”

Section: Discussionmentioning

confidence: 58%

“…2 Despite its overall safety record, doxycycline has been reported to have caused side effects, such as pseudotumor cerebri and drug reaction with eosinophilia and systemic symptoms (DRESS syndrome). [3][4][5][6] In our case report, doxycycline is believed to have caused cutaneous inflammation after a 2year course of treatment for acne vulgaris with recurrence on rechallenge of the medication.…”

mentioning

confidence: 72%

Doxycycline-Induced Cutaneous Inflammation with Systemic Symptoms in a Patient with Acne Vulgaris

Weinstein

Laxer²,

Debosz³

et al. 2013

J Cutan Med Surg

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DRESS syndrome sous doxycycline

Cited by 13 publications

References 12 publications

Comparison of the Efficacy of Azithromycin Versus Doxycycline in Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials

Comparison of the Efficacy of Azithromycin Versus Doxycycline in Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Doxycycline-Induced Cutaneous Inflammation with Systemic Symptoms in a Patient with Acne Vulgaris

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