Dressings produced from PVA nanofibers containing chloramphenicol

Fraga, Gabriel Nardi; Dragunski, Douglas Cardoso; Vilsinski, Bruno H.; Azevedo, Camila Kauany da Silva; Wiggers, Helton José; Faria, Maria Graciela Iecher; Caetano, Josiane; Costa, Marcella Ribeiro da; Zanuto, Vitor Santaella; Rossin, Ariane Regina Souza; Gibin, Mariana Sversut

doi:10.1016/j.colsurfa.2023.131760

Cited by 9 publications

(3 citation statements)

References 87 publications

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“…This feature contributes a lot to maintaining structural moisture, which helps remove the film from the injured skin without damaging it [ 1 ]. On the other hand, water absorption can lead the fibre to swell, promoting a decrease in pores and reducing the water vapor permeation capacity [ 56 ]. Furthermore, the low WVTR values may be related to the low porosity of the films [ 57 ], demonstrated by scanning electron microscopy (SEM) ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

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Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

et al. 2023

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Natural products can be used as complements or as alternatives to synthetic drugs. Eugenia uniflora and Tropaeolum majus are natives of Brazil and have antimicrobial, anti-inflammatory, and antioxidant activities. This study aimed to develop a film-forming system (FFS) loaded with plant extracts with the potential for treating microbial infections. E. uniflora and T. majus leaf extracts were prepared and characterized, and the individual and combined antioxidant and antimicrobial activities were evaluated. The FFS was developed with different concentrations of polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) and analyzed for physicochemical characteristics. The combination of extracts showed a superior antioxidant effect compared to the individual extracts, justifying the use of the blend. FFS prepared with 4.5% PVA, 4.5% PVP, 7.81% E. uniflora extract, and 3.90% T. majus extract was adhesive, lacked scale formation, presented good malleability, and had a suitable pH for topical application. In addition, the viscosity at rest was satisfactory for maintaining stability; water solubility was adequate; skin permeation was low; and the antimicrobial effect was superior to that of the individual extracts. Therefore, the developed FFS is promising for the differentiated treatment of skin lesions through topical application.

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Section: Resultsmentioning

confidence: 99%

“…7301, Aurora, IL, USA). For each sample, the assay was performed in triplicate, and the average of the evaluation parameters was obtained [ 56 ].…”

Section: Methodsmentioning

confidence: 99%

Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

et al. 2023

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“…This study used water-soluble polyvinyl alcohol (PVA), a prevalent excipient in pharmaceutical formulations, as a foundational matrix for nanofiber-encapsulating siR-NAs, a category of nucleic acid therapeutics. Recent reports have demonstrated the virtue of PVA nanofibers in drug delivery applications, highlighting their potential for controlled release and biocompatibility [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Development of Polyvinyl Alcohol (PVA) Nanofibers Containing Cationic Lipid/siRNA Complexes via Electrospinning: The Impact of PVA Characterization

Kanamori,

Hara,

Yamazoe

et al. 2024

Nanomaterials

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This study aimed to develop polyvinyl alcohol (PVA) nanofibers encapsulating 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)/siRNA complexes via electrospinning for the delivery of nucleic acid-based drugs. It also focused on the influence of the intrinsic properties of PVA on the efficacy of the system. PVA nanofibers, with diameters of 300–400 nm, were obtained, within which the siRNA remained intact and the DOTAP/siRNA complexes were uniformly dispersed. By incorporating DOTAP/siRNA complexes into the PVA nanofibers and assessing the impact of their RNA interference (RNAi) activity in A549-Luc cells, a stable inhibition of luciferase expression was observed. An examination of the nanofiber preparation process revealed that even when DOTAP or siRNA were added separately to the PVA solution without forming complexes, the RNAi effect was retained. The DOTAP/siRNA complexes released from the PVA nanofibers were internalized by the cells, with some PVA residues remaining on their surfaces. The significance of the degree of hydrolysis and polymerization of PVA on the performance of nanofibers was highlighted. Notably, PVA with a low degree of hydrolysis substantially enhanced RNAi effects, with luciferase expression inhibition reaching 91.5 ± 0.7%. Nanofibers made of PVA grades with anionic or cationic modifications were also evaluated, suggesting that they affect the efficacy of siRNA delivery. The insights obtained suggest avenues for future research to optimize drug delivery systems further.

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Influence of Lamotrigine concentration on physicochemical properties and transdermal release using PBAT/PLA electrospun fibers

Cândido,

Fraga,

Rossin

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Dressings produced from PVA nanofibers containing chloramphenicol

Cited by 9 publications

References 87 publications

Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

Development of Polyvinyl Alcohol (PVA) Nanofibers Containing Cationic Lipid/siRNA Complexes via Electrospinning: The Impact of PVA Characterization

Influence of Lamotrigine concentration on physicochemical properties and transdermal release using PBAT/PLA electrospun fibers

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