Dried fruit extract from Xylopia aethiopica (Annonaceae) protects Wistar albino rats from adverse effects of whole body radiation

Adaramoye, Oluwatosin A.; Okiti, Osume O.; Farombi, Ebenezer O.

doi:10.1016/j.etp.2010.05.005

Cited by 39 publications

(22 citation statements)

References 30 publications

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“…raising the issue of the use of this medicinal plant as spice. By contrast, other studies have found that X. aethiopica extract protects rats against the adverse effects of γ irradiation [9,10], suggesting that X. aethiopica extract contains both DNA damaging agents and protecting agents against the DNA damaging effect of irradiation.…”

Section: Resultsmentioning

confidence: 80%

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Characterization of the antiproliferative activity of Xylopia aethiopica

et al. 2012

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BackgroundXylopia aethiopica, a plant found throughout West Africa, has both nutritional and medicinal uses. The present study aims to characterize the effects of extracts of this plant on cancer cells.ResultsWe report that X. aethiopica extract prepared with 70% ethanol has antiproliferative activity against a panel of cancer cell lines. The IC50 was estimated at 12 μg/ml against HCT116 colon cancer cells, 7.5 μg/ml and > 25 μg/ml against U937 and KG1a leukemia cells, respectively. Upon fractionation of the extract by HPLC, the active fraction induced DNA damage, cell cycle arrest in G1 phase and apoptotic cell death. By using NMR and mass spectrometry, we determined the structure of the active natural product in the HPLC fraction as ent-15-oxokaur-16-en-19-oic acid.ConclusionThe main cytotoxic and DNA-damaging compound in ethanolic extracts of Xylopia aethiopica is ent-15-oxokaur-16-en-19-oic acid.

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Section: Resultsmentioning

confidence: 80%

“…Several studies have shown that X. aethiopica extracts possess antibacterial [2-5], antifungal [6] and anti-plasmodial [7] activities. X. aethiopica extract contains an antioxidant activity [8]; it also increases antioxidant defense and protects rats from the adverse effects of irradiation [9,10]. …”

Section: Introductionmentioning

confidence: 99%

Characterization of the antiproliferative activity of Xylopia aethiopica

et al. 2012

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“…[72][73][74][75] The dried fruit extract from Xylopia aethiopica (XA) increased the antioxidant defence systems in the liver, kidney, brain and testis of irradiated animals, and may protect from adverse effects of the whole body radiation. [76][77][78] Hippophae rhamnoides (Sea Buckthorn), has been reported to exhibit significant radioprotection against whole body lethal irradiation by preventing radiation induced DNA damage. [79] The PnA1 extract of the plant Ageratum conyzoides Linn (Sahadevi) (ACE) was found to scavenge (2,2-diphenyl-1-picrylhydrazyl) DPPH radicals in a concentration-dependent manner, indicating that the radioprotection afforded by ACE may be in part due to the scavenging of reactive oxygen species induced by ionizing radiation.…”

Section: Miscellaneousmentioning

confidence: 99%

A review of radioprotective plants

Bhandari¹

2013

Int J Green Pharm

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Radioprotective compounds have been used to diminish morbidity or mortality produced by ionizing irradiation. Initial developments of such agents concentrated on thiol synthetic compounds, like amifostine. This agent decreased mortality; however, there were difficulties in administering aminothiols that led to adverse effects. Unfortunately, no ideal, safe synthetic radioprotectors are available to date; hence, the exploration for other sources, including plants, has been ongoing for several decades. A methodical screening strategy can offer leads to isolating prospective novel candidate drugs from plant sources, for alleviation of radiation injury. This article reviews some of the most promising plants, and their bioactive principles, that are extensively used in traditional systems of medicine, and which have rendered noteworthy radioprotection in both in vitro and in vivo model systems.

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“…Scientific investigations have ascribed the following activities to the fruits of XYA; anti-diabetic ( The fruit extracts have also been found to offer protection against radiation in experimental animals (Adaramoye et al, 2010). Among these reported effects, xylopic acid (XA) has been found to be the main active principle responsible for the anti-nociceptive, antiinflammatory and analgesic effects , Woode et al, 2015 as well as antiplasmodial and spermatogenic (Woode et al, 2012a) effects.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Xylopic Acid and Chromatographic Fingerprint Evaluations of the Dried Fruits of Xylopia Aethiopica From Four African Countries

Alolga

Assanhou

Onoja

2018

Afr J Tradit Complement Altern Med

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Background: The fruits of Xylopia aethiopica (Dunal) A. Rich, (herein called XYA), family Annonaceae, commonly known as "Guinea pepper", "Ethiopian pepper" or "Negro pepper", are widely used in traditional African medicines to treat a wide array of diseases including malaria, fungal infections, rheumatism, arthritis, etc. Scientific investigations have ascribed the following activities to the fruits of XYA; anti-diabetic, anti-inflammatory, antimicrobial, antiplasmodial, analgesic, anti-nociceptive, anti-proliferative, spermatogenic and neuropharmacological effects. The main active principle reported is xylopic acid (XA), a kaurene diterpene. This study aimed to develop and validate a simple HPLC/UV (high performance liquid chromatography -ultraviolet detection) analytical method for the quantification of XA that can be reproduced in poor-resource settings where advanced analytical detection techniques such as HPLC-MS are unavailable. Materials and Methods: Thus in this study, a simple C18 solid-phase extraction (SPE) column-pretreatment ─ HPLC/UV analytical procedure was developed for the quantification of XA in the dried fruits of XYA from four African countries, Benin, Cameroon, Ghana and Nigeria. The samples of XYA from the four countries were assessed for similarities using chromatographic fingerprinting. Results: The HPLC method was validated for linearity, limits of detection and quantification, precision and accuracy. The samples of XYA from Cameroon were found to have the highest average content of XA while those from Benin had the lowest average content of XA.

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Dried fruit extract from Xylopia aethiopica (Annonaceae) protects Wistar albino rats from adverse effects of whole body radiation

Cited by 39 publications

References 30 publications

Characterization of the antiproliferative activity of Xylopia aethiopica

Characterization of the antiproliferative activity of Xylopia aethiopica

A review of radioprotective plants

Quantification of Xylopic Acid and Chromatographic Fingerprint Evaluations of the Dried Fruits of Xylopia Aethiopica From Four African Countries

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