Dried fruit extract of<i>Terminalia chebula</i>modulates the immune response in mice

Rubab, Ishrina; Ali, Shakir

doi:10.1080/09540105.2015.1055554

Cited by 21 publications

(11 citation statements)

References 48 publications

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“…Th1 responses support cell-mediated immunity, whereas Th2 responses support humoral immunity against infection (Rubab & Ali, 2016). Both Th1 responses and Th2 Figure 7.…”

Section: Discussionmentioning

confidence: 99%

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Xiu

Zhang

et al. 2018

Food and Agricultural Immunology

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Exopolysaccharides act as mediators of cross-talk between probiotics and the host. Here, we found that EPS derived from probiotic Lactobacillus casei WXD030 strain (L-EPS) could modulate immune responses in vitro and in vivo. L-EPS could significantly enhance the proliferation and phagocytic activity as well as induce the production of NO, TNF-α, IL-1β and IL-6 in RAW264.7 cells. Furthermore, L-EPS could induce the maturation of BMDCs. In addition, L-EPS could largely increase the titres of OVA-specific antibodies and markedly enhanced T cell proliferation. Notably, L-EPS also increased expression of IL-4 and INF-γ expression in CD4 + T cells. Consistently, when used as an adjuvant in vivo with the foot-and-mouth disease vaccine, L-EPS largely enhanced the FMDVspecific antibody production. Collectively, these results suggested that L-EPS derived from probiotic L. casei strain had adjuvant activity, which may be a safe and efficacious adjuvant candidate suitable for a wide spectrum of prophylactic and therapeutic vaccines.

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“…Th1 responses support cell-mediated immunity, whereas Th2 responses support humoral immunity against infection (Rubab & Ali, 2016). Both Th1 responses and Th2 Figure 7.…”

Section: Discussionmentioning

confidence: 99%

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Xiu

Zhang

et al. 2018

Food and Agricultural Immunology

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“…Also, anthraquinones, chebulagic acid, chebulinic acid, ellagic acid, gallic and ethaedioc acid, terpinenes and terpineols and 4,2,4-chebulyl-β -D-glucopyranose have been identified in this species [54,556,559]. The result of Vaibhav et al [554] and Rubab and Ali [562] demonstrated the immunomodulatory activity of T. chebula. The antibacterial property of the plant is attributed to the heat stable compounds with possible therapeutic potential [563].…”

Section: Terminalia Chebula (Combretaceae)mentioning

confidence: 83%

Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects

Tiwari

Latheef

Ahmed

et al. 2018

CDM

121

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“…In an attempt to explore the function of T. chebula extract in augmenting the antigen‐specific Th1/Th2 immune responses in mice model, it was reported that T. chebula enhanced the Ig secretion, increased T‐cell proliferation, elevate macrophage mediated phagocytosis and documented an inclination towards Th1‐type immunity. These outcomes thus proved T. chebula as a stimulator of the humoral, cell‐mediated and innate immunity (Rubab & Ali, 2016). T. chebula (aqueous and alcoholic extracts) has been reported to intensify the activation of macrophages (Belapurkar, Goyal, & Tiwari‐Barua, 2014).…”

Section: Pharmacological Activitiesmentioning

confidence: 90%

Fruits ofTerminalia chebulaRetz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities

Nigam

Mishra

Adhikari‐Devkota

et al. 2020

Phytotherapy Research

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Fruits of Terminalia chebula Retz. (Combretaceae) are widely used as crude drugs in various traditional medicine systems. The aim of this article is to review the available scientific information regarding the traditional uses, bioactive chemical constituents and the pharmacological activities of T. chebula. Numerous researches conducted on T. chebula have confirmed the presence of wide range of the phytochemicals such as flavonoids, tannins, phenolic acids and other bioactive compounds. T. chebula is also widely studied regarding its pharmacological activities such as antioxidant, hepatoprotective, neuroprotective, cytotoxic, antidiabetic, anti-inflammatory activities among others. However, more in vivo and clinical studies for mechanism-based pharmacological evaluation should be conducted in future to provide stronger scientific evidences for their traditional uses.

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Dried fruit extract ofTerminalia chebulamodulates the immune response in mice

Cited by 21 publications

References 48 publications

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo

Herbal Immunomodulators - A Remedial Panacea for Designing and Developing Effective Drugs and Medicines: Current Scenario and Future Prospects

Fruits ofTerminalia chebulaRetz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities

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