In the aerospace field, difficult-to-machine materials are used widely to improve engine performance. As a nickel-based material that performs well in all aspects, Inconel 625 is used for the blisks of aircraft engines, and electrochemical trepanning (ECTr) is used widely to fabricate such blisks because of its unique advantages regarding ruled surface parts. In this study, to investigate the performance of Inconel 625 in ECTr, measurements were made of the electrochemical characteristics firstly, specifically the anodic polarization curve and the actual volumetric electrochemical equivalent curve. Then, via dynamic electric-field simulations, the processes for forming Inconel 625 blades using ECTr were examined under direct voltage (DV) and pulsed voltage. The contours and current density distributions of formed blades at different times were obtained under different duty cycles. With decreasing duty cycle, the forming accuracy improved gradually and the stray current was reduced. To verify the simulation results, ECTr experiments with Inconel 625 were performed under different voltage conditions. With DV and 90% and 80% duty cycle, the taper angles of the machined blades were 7.784°, 6.278°, and 5.191°, respectively, and the surface roughness ( Ra) values were 0.95, 0.81, and 0.72 μm, respectively. With DV, there were obvious flow marks and gullies on the microscopic surface. With decreasing duty cycle, stray corrosion was reduced effectively and the state of the flow field was improved. Overall, the simulation results were verified effectively.