Drimane-type Sesquiterpene Coumarins from Ferula gummosa Fruits Enhance Doxorubicin Uptake in Doxorubicin-resistant Human Breast Cancer Cell Line

Iranshahi, Mehrdad; Barthomeuf, Chantal; Bayet-Robert, Mathilde; Chollet, Philippe; Davoodi, Davood; Piacente, Sonia; Rezaee, Ramin; Sahebkar, Amirhossein

doi:10.4103/2225-4110.126181

Cited by 35 publications

(21 citation statements)

References 15 publications

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“…Anthracyclines are a class of drugs used in cancer chemotherapy isolated from Streptomyces bacterium . These compounds are used to treat many cancers, including leukemias, lymphomas, as well as breast, stomach, uterine, ovarian, bladder cancer, and lung cancers ( 5 – 7 ). The first anthracycline discovered was daunorubicin (trade name Daunomycin), which is produced naturally by Streptomyces peucetius , a species of actinobacteria.…”

Section: Introductionmentioning

confidence: 99%

What is considered cardiotoxicity of anthracyclines in animal studies Corrigendum in /10.3892/or.2020.7717

et al. 2020

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Anthracyclines are commonly used anticancer drugs with well-known and extensively studied cardiotoxic effects in humans. In the clinical setting guidelines for assessing cardiotoxicity are well-established with important therapeutic implications. Cardiotoxicity in terms of impairment of cardiac function is largely diagnosed by echocardiography and based on objective metrics of cardiac function. Until this day, cardiotoxicity is not an endpoint in the current general toxicology and safety pharmacology preclinical studies, although other classes of drugs apart from anthracyclines, along with everyday chemicals have been shown to manifest cardiotoxic properties. Also, in the relevant literature there are not well-established objective criteria or reference values in order to uniformly characterize cardiotoxic adverse effects in animal models. This in depth review focuses on the evaluation of two important echocardiographic indices, namely ejection fraction and fractional shortening, in the literature concerning anthracycline administration to rats as the reference laboratory animal model. The analysis of the gathered data gives promising results and solid prospects for both, defining anthracycline cardiotoxicity objective values and delineating the guidelines for assessing cardiotoxicity as a separate hazard class in animal preclinical studies for regulatory purposes.

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Section: Introductionmentioning

confidence: 99%

What is considered cardiotoxicity of anthracyclines in animal studies Corrigendum in /10.3892/or.2020.7717

et al. 2020

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“…[9] Sesquiterpene coumarins present various pharmacological properties. [10,11] UMB was shown to exert anticancer, anti-inflammatory and immunomodulatory effects, [12,13] along with anti-nociceptive and anti-neuropathic pain properties. [14,15] Many in vitro and in vivo studies confirmed its antioxidant, anti-inflammatory effects; UMB has been shown to inhibit lipoxygenase, managing in this way inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Umbelliprenin relieves paclitaxel-induced neuropathy

Shahraki

Rezaee

Kenar

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Umbelliprenin (UMB) is a prenylated coumarin that acts as an in vitro antioxidant and inhibits lipoxygenase managing the inflammation pathways, while in vivo it exerts anti-inflammatory activities. Methods In this study, neuropathic pain was induced by four intraperitoneal doses of 2 mg/kg per day of paclitaxel (PTX) on days 1, 3, 5 and 7. Here, 49 male mice were randomly divided in the following groups: sham (not treated animals), negative control (PTX-treated receiving normal saline), single-dose UMB 6.25, 12.5 and 25 mg/kg groups (PTX-treated receiving UMB 6.25, 12.5 and 25 mg/kg, respectively), prevention (PTX-treated receiving PTX along with UMB 12.5 mg/ kg on days 1, 3, 5 and 7) and positive control group (PTX-treated receiving imipramine 10 mg/kg as acute treatment). Hot-plate test was done to assess response to heat. Finally, interleukin (IL)-6 levels in the sciatic nerve and lipid peroxidation in sera were assessed. Key findings Umbelliprenin was found equally effective for acute treatment with imipramine, when comparing the prevention group and the positive control group. Single, 25 mg/kg UMB effectively attenuated hyperalgesia, lipid peroxidation and IL-6 levels. Conclusions Umbelliprenin alleviated neuropathic pain, and decreased serum IL-6 levels and oxidative stress. UMB deserves further investigations, especially in clinical settings.

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“…Researches on cytotoxic and cancer preventing activities and hormonal effects of Ferula species have an increasing interest in recent years. Activities are generally related to the daucane sesquiterpenes and coumarin derivatives as the main metabolite groups of genus [7][8][9][10][11][12][13]. Especially ferutinin (a daucane type sesquiterpene ester) has been reported as a phytoestrogen acting as agonist for ER-α and agonist/antagonist for ER-β [14].…”

Section: Introductionmentioning

confidence: 99%

Ferutinin content and cytotoxic effects of various Ferula L. species on prostate cancer (PC-3) cell line

Baykan¹,

Aydoğan²,

Öztürk³

et al. 2020

jrp

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Ferula L. is represented by 23 taxa in Turkish flora. Most of the species are known as "Caksır" and roots are used as aphrodisiac in Anatolia. The aim of this study is to investigate the cytotoxic potential of roots of twelve different Ferula L. species distributing in Anatolia on prostate cancer cell line PC-3. Three extracts with different polarity were prepared from grounded roots of plants by ultrasonic solvent extraction. WST assay was performed to evaluate the cytotoxic effects of extracts. High cytotoxic activity was observed in F. elaeochytris, F. drudeana chloroform extracts and F. szowitsiana hexane extract (IC50: 3.21±0.24µg/ml, 5.92±0.53µg/ml, 8.03±0.51µg/ml respectively) whereas methanol extracts of all species had no cytotoxic activity. F. tingitana chloroform extract induced high proliferation in dose dependent manner. A daucane ester "ferutinin" content was evaluated among the extracts by UPLC and it is found in highest concentrations in F. tenuissima and F. halophila hexane extracts (167380 µg/g and 157160 µg/g respectively). Although there is not a direct relationship between ferutinin content and cytotoxicity on PC-3, F. elaeochytris, F. drudeana, F. szowitsiana and F. tenuissima can be good candidates for the further studies for finding lead phytochemical compounds for prostate cancer treatment.

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Drimane-type Sesquiterpene Coumarins from Ferula gummosa Fruits Enhance Doxorubicin Uptake in Doxorubicin-resistant Human Breast Cancer Cell Line

Cited by 35 publications

References 15 publications

What is considered cardiotoxicity of anthracyclines in animal studies Corrigendum in /10.3892/or.2020.7717

What is considered cardiotoxicity of anthracyclines in animal studies Corrigendum in /10.3892/or.2020.7717

Umbelliprenin relieves paclitaxel-induced neuropathy

Ferutinin content and cytotoxic effects of various Ferula L. species on prostate cancer (PC-3) cell line

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