Drinking alkaline mineral water confers diarrhea resistance in maternally separated piglets by maintaining intestinal epithelial regeneration via the brain-microbe-gut axis

Chen, Jian; Zhao, Bi-Chen; Dai, Xueyan; Xu, Yaru; Kang, Jian-Xun; Li, Jinlong

doi:10.1016/j.jare.2022.12.008

Cited by 19 publications

(14 citation statements)

References 70 publications

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“…Immunofluorescence (IF) was performed according to our previous study. , The IF staining of brain tissues is described in detail in Supporting Information Methods 1.2 and 1.3 and analyzed using a fluorescence microscope (Leica, Germany).…”

Section: Methodsmentioning

confidence: 99%

Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

Zhao,

Chang,

Ren

et al. 2024

J. Agric. Food Chem.

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phthalate (DEHP), as the most common phthalate, has been extensively used as a plasticizer to improve the plasticity of agricultural products, which pose severe harm to human health. Mitochondrial dynamics and endoplasmic reticulum (ER) homeostasis are indispensable for maintaining mitochondria-associated ER membrane (MAM) integrity. In this study, we aimed to explore the effect of DEHP on the nervous system and its association with the ER−mitochondria interaction. Here, we showed that DEHP caused morphological changes, motor deficits, cognitive impairments, and blood−brain barrier disruption in the brain. DEHP triggered ER stress, which is mainly mediated by protein kinase R-like endoplasmic reticulum kinase (PERK) signaling. Moreover, DEHP-induced mitofusin-2 (Mfn2) downregulation results in imbalance of the mitochondrial dynamics. Interestingly, DEHP exposure impaired MAMs by inhibiting the Mfn2-PERK interaction. Above all, this study elucidates the disruption of the Mfn2-PERK axis-mediated ER−mitochondria interaction as a phthalate-induced neurotoxicity that could be potentially developed as a novel therapy for neurological diseases.

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Section: Methodsmentioning

confidence: 99%

Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

Zhao,

Chang,

Ren

et al. 2024

J. Agric. Food Chem.

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“…More and more evidence has suggested that the IECs immunomodulatory capacity is well involved in the pathogenesis and progression of multiple colon diseases [35] , [36] . In response to inflammatory signals, IECs secrete many inflammatory cytokines/chemokines to affect the local accumulation of lymphoid cells, such as CD19 + B cells, T cells, NKTs, and γδ + T cells, as well.…”

Section: Discussionmentioning

confidence: 99%

The miR-7/EGFR axis controls the epithelial cell immunomodulation and regeneration and orchestrates the pathology in inflammatory bowel disease

Zhao

Guo

Yan

et al. 2024

Journal of Advanced Research

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“…Protein samples were separated by 6 to 10% SDS-PAGE and transferred onto a NC membrane. The detail procedure of western blotting is shown in our previous report ( Chen et al, 2023b ). The PVDF or NC membranes with proteins were imaged by Amersham Imager 600 (GE, Switzerland).…”

Section: Methodsmentioning

confidence: 99%

Inhibition of mtDNA-PRRs pathway-mediated sterile inflammation by astragalus polysaccharide protects against transport stress-induced cardiac injury in chicks

Chen,

Xu,

et al. 2024

Poultry Science

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Drinking alkaline mineral water confers diarrhea resistance in maternally separated piglets by maintaining intestinal epithelial regeneration via the brain-microbe-gut axis

Cited by 19 publications

References 70 publications

Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum–Mitochondria Interaction

The miR-7/EGFR axis controls the epithelial cell immunomodulation and regeneration and orchestrates the pathology in inflammatory bowel disease

Inhibition of mtDNA-PRRs pathway-mediated sterile inflammation by astragalus polysaccharide protects against transport stress-induced cardiac injury in chicks

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