Drinking Elicited by Polyethylene Glycol and Isoproterenol Reduced by Antiserum to Angiotensin II

Abdelaal, A. E.; Mercer, Paul F.; Mogenson, Gordon J.

doi:10.1139/y74-050

Cited by 31 publications

(2 citation statements)

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“…Hypovolemia causes renin release and, as noted earlier, a blockade of angiotensin's actions (Abdelaal, Mercer, & Mogenson, 1974) or ablation of the subfornical organ (Simpson et aI., 1977) reduce hypovolemic drinking by half in the rat. In their recent experiments Fitzsimons and Moore-Gillon demonstrated that acute obstruction of the venous return raised the plasma renin levels of their dogs, and that competitive inhibition of angiotensin action with infusions of Saralasin prolonged the latency of the onset of their drinking and reduced its amount.…”

Section: N Onhormonal Afferents Of Hypovolemic Thirstmentioning

confidence: 70%

The Physiological Mechanisms of Motivation

Pfaff¹

1982

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Section: N Onhormonal Afferents Of Hypovolemic Thirstmentioning

confidence: 70%

The Physiological Mechanisms of Motivation

Pfaff¹

1982

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“…Systemic injections of isoprenaline cause drinking in rats (Zamboni & Siro-Brigiani, 1966;Lehr, Mallow & Krukowski, 1967;Peskar, Leodolter & Hertting, 1970;Abdelaal, Mercer & Mogenson, 1974Leenen & Stricker, 1974), and dogs (Fitzsimons & Szczepanska-Sadowska, 1974;Rolls & Ramsay, 1975). Isoprenaline J. ATKINSON AND OTHERS peripheral isoprenaline in the rat (Meyer, Peskar & Hertting, 1971;Houpt & Epstein, 1971).…”

Section: Introductionmentioning

confidence: 99%

The role of circulating renin in drinking in response to isoprenaline

Atkinson

Kaesermann

Lambelet

et al. 1979

The Journal of Physiology

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SUMMARY1. In nephrectomized rats, s.c. (0*12 mg.kg body wt.-') or intracerebroventricular (i.c.v.: 0-03 mg. kg-'), isoprenaline failed to elicit drinking. However, when preceded (5-20 min) by a non-dipsogenic dose of i.v. pig renin, s.c. isoprenaline induced a marked, and i.c.v. isoprenaline a smaller drinking response. 2 hr after i.v. renin, s.c. isoprenaline no longer caused drinking.2. Pig renin did not enhance drinking in response to 0*12 mg.kg-' isoprenaline s.c. in intact or sham-operated rats.3. Isoprenaline (0.12 mg.kg body wt.-', s.c.) caused a larger fall of blood pressure in unanaesthetized nephrectomized than in intact unanaesthetized rats, but it was not the resulting hypotension that interfered with the nephrectomized rats' ability to drink, since intact rats with similar falls in blood pressure drank avidly in response to large doses of isoprenaline.4. Since the rate of inactivation of pig renin in nephrectomized rats was not modified by isoprenaline, drinking in nephrectomized animals in response to renin + isoprenaline was not attributable to increased plasma renin levels.5. Since isoprenaline induces drinking in the presence of circulating renin, but in the absence of renin release from kidneys, renin plays a permissive role in isoprenaline-induced drinking. Angiotensin and isoprenaline may interact at the level of intracranial receptors.

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