Drinking patterns and the risk of serious liver disease

Brandish, Emma K.; Sheron, Nick

doi:10.1586/egh.10.27

Cited by 14 publications

(11 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detailed data from drinking diaries for these patients, which have previously been used to report patterns of drinking, 12 were incorporated, where appropriate. The methods for this additional cohort were identical to those for the major cohort, except that they had not been asked questions about expenditure on alcohol.…”

Section: Methodsmentioning

confidence: 99%

Impact of minimum price per unit of alcohol on patients with liver disease in the UK

et al. 2014

Self Cite

View full text Add to dashboard Cite

The slow epidemic of liver disease in the UK over the past 30 years is a result of increased consumption of strong cheap alcohol. When we examined alcohol consumption in 404 subjects with a range of liver disease, we confi rmed that patients with alcohol-related cirrhosis drank huge amounts of cheap alcohol, with a mean weekly consumption of 146 units in men and 142 in women at a median price of 33p/unit compared with £1.10 for low-risk drinkers. For the patients in our study, the impact of a minimum unit price of 50p/unit on spending on alcohol would be 200 times higher for patients with liver disease who were drinking at harmful levels than for low-risk drinkers. As a health policy, a minimum unit price for alcohol is exquisitely targeted at the heaviest drinkers, for whom the impact of alcohol-related illness is most devastating.

show abstract

Section: Methodsmentioning

confidence: 99%

Impact of minimum price per unit of alcohol on patients with liver disease in the UK

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Of further note, a similarly selectively-bred strain of high (HAP) and low (LAP) alcohol preference mice has been developed from a HS/ibg progenitor line (Brandish and Sheron, 2010; Matson and Grahame, 2011). Following selection, mice were cross-mated to non-sibling or first cousin pairs in order to “ fix ” alleles that may contribute to neurobehavioral characteristics of alcoholics (Brandish and Sheron, 2010).…”

Section: Animal Models Of Alcohol Ingestionmentioning

confidence: 99%

“…Following selection, mice were cross-mated to non-sibling or first cousin pairs in order to “ fix ” alleles that may contribute to neurobehavioral characteristics of alcoholics (Brandish and Sheron, 2010). Mice offer the advantage of possessing well-characterized genomes, combined with lower purchase and animal husbandry costs.…”

Section: Animal Models Of Alcohol Ingestionmentioning

confidence: 99%

Rodent models of alcoholic liver disease: Of mice and men

Brandon-Warner

Schrum

Schmidt

et al. 2012

Alcohol

118

View full text Add to dashboard Cite

Alcoholic liver disease (ALD) is a major cause of acute and chronic liver disease worldwide. The progressive nature of ALD is well described however the complex interactions under which these pathologies evolve remain to be fully elucidated. Clinically there are no clear biomarkers or universally accepted, effective treatment strategies for ALD. Experimental models of ALD are an important component in identifying underlying mechanisms of alcohol-induced injury to develop better diagnostic markers, predictors of disease progression, and therapeutic targets to manage, halt, or reverse disease progression. Rodents remain the most accessible model for studying ALD pathology. Effective rodent models must mimic the natural history of ALD while allowing examination of complex interactions between multiple hepatic, and non-hepatic, cell types in the setting of altered metabolic or oxidative/nitrosative stress, inflammatory responses, and sensitivity to cytotoxic stress. Additionally, mode and duration of alcohol delivery influences hepatic response and presents unique challenges in understanding disease pathology. This review provides an overview of rodent models of ALD, their strengths and weaknesses relative to human disease states, and provides insight of the potential to develop novel rodent models to simulate the course of human ALD.

show abstract

“…A second possible explanation for these findings is that drinking pattern of spirits users was substantially different from wine or beer users. There is suggestive evidence that consumption of spirits is more closely associated with larger quantities of alcohol consumed per occasion [34]. Surprisingly, the size of the bivariate association between vodka sales and alcohol poisoning mortality rates for women is higher than for men.…”

Section: Discussionmentioning

confidence: 99%

The Differential Effects of Beverage Type on Alcohol Poisoning Mortality in Russia

2014

J Alcohol Drug Depend

View full text Add to dashboard Cite

show abstract

Drinking patterns and the risk of serious liver disease

Cited by 14 publications

References 31 publications

Impact of minimum price per unit of alcohol on patients with liver disease in the UK

Impact of minimum price per unit of alcohol on patients with liver disease in the UK

Rodent models of alcoholic liver disease: Of mice and men

The Differential Effects of Beverage Type on Alcohol Poisoning Mortality in Russia

Contact Info

Product

Resources

About