Drinking water arsenic exposure and blood pressure in healthy women of reproductive age in Inner Mongolia, China

Kwok, Richard K.; Mendola, Pauline; Liu, Zhiyi; Savitz, David A.; Heiss, Gerardo; Ling, He Ling; Xia, Yajuan; Lobdell, Danelle T.; Zeng, Donglin; Thorp, John M.; Creason, John P.; Mumford, Judy L.

doi:10.1016/j.taap.2007.04.003

Cited by 75 publications

(51 citation statements)

References 32 publications

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“…Exposure to arsenic is increasingly linked to adverse effects on cardiovascular health, including increased atherosclerosis, 31 hypertension, 32,33 ischemic heart disease, 31,34 and arteriosclerosis. 35 Despite this mounting evidence, the molecular mechanisms involved remain unresolved.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Liver X Receptor/Retinoid X Receptor–Mediated Transcription Contributes to the Proatherogenic Effects of Arsenic in Macrophages In Vitro

Padovani

Molina

Mann

2010

ATVB

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Objective-To determine whether arsenic inhibits transcriptional activation of the liver X receptor (LXR)/retinoid X receptor (RXR) heterodimers, thereby impairing cholesterol efflux from macrophages and potentially contributing to a proatherogenic phenotype. Methods and Results-Arsenic is an important environmental contaminant and has been linked to an increased incidence of atherosclerosis. Previous findings showed that arsenic inhibits transcriptional activation of type 2 nuclear receptors, known to heterodimerize with RXR. Environmentally relevant arsenic doses decrease the LXR/RXR ligand-induced expression of the LXR target genes . Arsenic failed to decrease cAMP-induced ABCA1 expression, suggesting a selective LXR/RXR effect. This selectivity correlated with the ability of arsenic to decrease LXR/RXR ligand-induced, but not cAMP-induced, cholesterol efflux. By using chromatin immunoprecipitation assays, we found that arsenic inhibits the ability of LXR/RXR ligands to induce activation markers on the ABCA1 and SREBP-1c promoters and blocks ligand-induced release of the nuclear receptor coexpressor (NCoR) from the promoter. Arsenic did not alter the ability of LXR to transrepress inflammatory gene transcription, further supporting our hypothesis that RXR is the target for arsenic inhibition. Conclusion-Exposure to arsenic enhances the risk of atherosclerosis. We present data that arsenic inhibits the transcriptional activity of the liver X receptor, resulting in decreased cholesterol-induced gene expression and efflux from macrophages. Therefore, arsenic may promote an athersclerotic environment by decreasing the ability of macrophages to efflux excess cholesterol, thereby favoring increased plaque formation. Key Words: atherosclerosis Ⅲ macrophages Ⅲ receptors Ⅲ arsenic Ⅲ liver X receptor A rsenic has been widely known as a carcinogen; however, recent evidence suggests that those exposed to arsenic also have an increased risk for diabetes mellitus and cardiovascular diseases. In humans, a consequence of arsenic exposure is Blackfoot disease, which is characterized by severe peripheral arteriosclerosis. [1][2][3] Copper smelt workers exposed to arsenic were reported to have increased mortality from ischemic heart disease. 4,5 A significant correlation was found in an area of Taiwan between length of exposure to arsenic in the ground water and the risk of ischemic heart disease. 6 In the United States, higher levels in the drinking water correlated with an increased risk of death from vascular disease. 7 More recently, arsenic accelerated carotid atherosclerosis, with a multivariate-adjusted odds ratio of 3.1. 8 In vivo and in vitro data support and correlate with these epidemiological data, although the mechanism by which arsenic increases atherosclerosis is unclear. Inflammation is a key component of the generation of atherosclerotic lesions, and increased inflammatory molecule expression after arsenic exposure has been reported. 9 Cells treated in vitro with arsenic have increased levels of 5-lipoxygenase, ...

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Section: Discussionmentioning

confidence: 99%

Inhibition of Liver X Receptor/Retinoid X Receptor–Mediated Transcription Contributes to the Proatherogenic Effects of Arsenic in Macrophages In Vitro

Padovani

Molina

Mann

2010

ATVB

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“…A crosssectional study in Inner Mongolia showed that chronic exposure to arsenic from drinking caused oxidative stress in humans [18]. Furthermore, a recent study demonstrated monotonic dose-response association between arsenic exposure from drinking water and elevated levels of systolic and diastolic blood pressure in a population of healthy women who are at the reproductive age [19]. In conclusion, the reduction of exposure to arsenic via drinking water still remains a challenge in China.…”

Section: Arsenismmentioning

confidence: 95%

Water Pollution and Health Impact in China: A Mini Review

Lu¹,

Xie²,

Zhou³

et al. 2008

TOENVIRSJ

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For the last 20-odd years in China, an economic boom has resulted in severe environmental pollution; water pollution, particularly, is of great concern. It has been reported that pollution in China's overall surface water is rated medium. The water quality of groundwater, lakes and reservoirs has deteriorated. Consequently, such a general distribution of water pollution has posed a grave threat to public health in China. The health impact of water pollution has been documented in the last several decades; these documents are reviewed in this paper on several outstanding aspects, including chronic mercurialism, arsenism, cancers related to microcystins, health problems caused by organic pollutants and water pollution accidents as well. Indubitably, water pollution and its health impact remain enormous challenges in China.

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“…Low-level inorganic arsenic exposure increases the risk of pre-malignant skin lesions, 9,10 hypertension 11,12 and neurological dysfunctions. 13 Observational studies in humans and experimental studies in animals have found arsenic to be potentially diabetogenic.…”

Section: Key Findingsmentioning

confidence: 99%

Arsenic exposure and type 2 diabetes: results from the 2007–2009 Canadian Health Measures Survey

Feseke

St-Laurent²,

Anassour-Sidi³

et al. 2015

Health Promot Chronic Dis Prev Can

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Introduction: Inorganic arsenic and its metabolites are considered dangerous to human health. Although several studies have reported associations between low-level arsenic exposure and diabetes mellitus in the United States and Mexico, this association has not been studied in the Canadian population. We evaluated the association between arsenic exposure, as measured by total arsenic concentration in urine, and the prevalence of type 2 diabetes (T2D) in 3151 adult participants in Cycle 1

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Drinking water arsenic exposure and blood pressure in healthy women of reproductive age in Inner Mongolia, China

Cited by 75 publications

References 32 publications

Inhibition of Liver X Receptor/Retinoid X Receptor–Mediated Transcription Contributes to the Proatherogenic Effects of Arsenic in Macrophages In Vitro

Inhibition of Liver X Receptor/Retinoid X Receptor–Mediated Transcription Contributes to the Proatherogenic Effects of Arsenic in Macrophages In Vitro

Water Pollution and Health Impact in China: A Mini Review

Arsenic exposure and type 2 diabetes: results from the 2007–2009 Canadian Health Measures Survey

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