Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects

Gerlai, Robert; Lahav, Meir; Guo, Sheng-Ya; Rosenthal, Arnon

doi:10.1016/s0091-3057(00)00422-6

Cited by 692 publications

(711 citation statements)

References 45 publications

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“…L/D choice behavior is similarly light-driven yet distinct in duration (observable within minutes to tens of minutes), and it has been reported in adult zebrafish (13,(21)(22)(23). After being individually introduced into a L/D choice chamber (light intensity readings of 300 and 160 Lux, respectively, on each side) (Fig.…”

Section: Resultsmentioning

confidence: 59%

Identification of a brain center whose activity discriminates a choice behavior in zebrafish

Lau

Mathur

Gould

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

183

194

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The ability to make choices and carry out appropriate actions is critical for individual survival and well-being. Choice behaviors, from hard-wired to experience-dependent, have been observed across the animal kingdom. Although differential engagement of sensory neuronal pathways is a known mechanism, neurobiological substrates in the brain that underlie choice making downstream of sensory perception are not well understood. Here, we report a behavioral paradigm in zebrafish in which a half-light/ half-dark visual image evokes an innate choice behavior, light avoidance. Neuronal activity mapping using the immediate early gene c-fos reveals the engagement of distinct brain regions, including the medial zone of the dorsal telencephalic region (Dm) and the dorsal nucleus of the ventral telencephalic area (Vd), the teleost anatomical homologs of the mammalian amygdala and striatum, respectively. In animals that were subjected to the identical sensory stimulus but displayed little or no avoidance, strikingly, the Dm and Vd were not engaged, despite similar levels of activation in the brain nuclei involved in visual processing. Based on these findings and previous connectivity data, we propose a neural circuitry model in which the Dm serves as a brain center, the activity of which predicates this choice behavior in zebrafish.emotion | fear | anxiety | decision-making

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Section: Resultsmentioning

confidence: 59%

Identification of a brain center whose activity discriminates a choice behavior in zebrafish

Lau

Mathur

Gould

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

183

194

View full text Add to dashboard Cite

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“…Relatively low doses of ethanol have been shown to induce hyperactivity in larval and adult zebrafish, while higher doses have been shown to reduce activity. 70,71 Thus, ethanol concentration is an important variable in the effect of ethanol on locomotion. mechanism by which ethanol teratogenicity proceeds.…”

Section: Zebrafish Models Of Fasdmentioning

confidence: 99%

Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis

2016

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Fetal Alcohol Spectrum Disorders (FASD) describes a wide array of ethanol-induced developmental defects, including craniofacial dysmorphology and cognitive impairments. It affects *1 in 100 children born in the United States each year. Due to the pleiotropic effects of ethanol, animal models have proven critical in characterizing the mechanisms of ethanol teratogenesis. In this review, we focus on the utility of zebrafish in characterizing ethanolinduced developmental defects. A growing number of laboratories have focused on using zebrafish to examine ethanol-induced defects in craniofacial, cardiac, ocular, and neural development, as well as cognitive and behavioral impairments. Growing evidence supports that genetic predisposition plays a role in these ethanol-induced defects, yet little is understood about these gene-ethanol interactions. With a high degree of genetic amenability, zebrafish is at the forefront of identifying and characterizing the gene-ethanol interactions that underlie FASD.

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“…Zebrafish display characteristic agonistic postures, including erection of the fins, biting, tail thrashing, and short bouts of fast swimming (Gerlai et al, 2000). Aggression is exhibited by both sexes (Moretz et al, 2007) and can be influenced by both habitat complexity and rearing conditions (Basquill and Grant, 1997;Marks et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Modulation of Fgfr1a Signaling in Zebrafish Reveals a Genetic Basis for the Aggression–Boldness Syndrome

Norton¹,

Stumpenhorst²,

et al. 2011

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Behavioral syndromes are suites of two or more behaviors that correlate across environmental contexts. The aggression-boldness syndrome links aggression, boldness, and exploratory activity in a novel environment. Although aggression-boldness has been described in many animals, the mechanism linking its behavioral components is not known. Here we show that mutation of the gene encoding fibroblast growth factor receptor 1a ( fgfr1a) simultaneously increases aggression, boldness, and exploration in adult zebrafish. We demonstrate that altered Fgf signaling also results in reduced brain histamine levels in mutants. Pharmacological increase of histamine signaling is sufficient to rescue the behavioral phenotype of fgfr1a mutants. Together, we show that a single genetic locus can underlie the aggression-boldness behavioral syndrome. We also identify one of the neurotransmitter pathways that may mediate clustering of these behaviors.

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Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects

Cited by 692 publications

References 45 publications

Identification of a brain center whose activity discriminates a choice behavior in zebrafish

Identification of a brain center whose activity discriminates a choice behavior in zebrafish

Fishing for Fetal Alcohol Spectrum Disorders: Zebrafish as a Model for Ethanol Teratogenesis

Modulation of Fgfr1a Signaling in Zebrafish Reveals a Genetic Basis for the Aggression–Boldness Syndrome

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