Drivers of maternal accumulation of organohalogen pollutants in Arctic areas (Chukotka, Russia) and 4,4′-DDT effects on the newborns

Bravo, Natalia; Grimalt, Joan O.; Chashchin, Maxim; Chashchin, Valery; Odland, Jon Øyvind

doi:10.1016/j.envint.2019.01.049

Cited by 24 publications

(28 citation statements)

References 60 publications

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“…Among HCH isomers, adipose tissue β-HCH levels were found at a substantially higher detection rate than α-HCH, probably because it exerts a markedly high resistance to chemical degradation both in the environment as living organisms [124], as found in previous research [27,29,30,32]. In the same way, this was observed in several studies that used other biological matrices different to adipose tissue such as blood [99][100][101][102][103]106], serum [45,72,76,77,81,86,87,125], plasma [49,58,109], and breast milk [52,53,55,57].…”

Section: Discussionsupporting

confidence: 69%

Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Salcedo‐Bellido

Amaya

Pérez-Díaz

et al. 2022

IJERPH

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To identify bioaccumulation patterns of α-, β- hexachlorocyclohexane (HCH) and dicofol in relation to sociodemographic, dietary, and lifestyle factors, adipose tissue samples of 387 subjects from GraMo cohort in Southern Spain were analyzed. Potential predictors of these organochlorine pesticides (OCP) levels were collected by face-to-face interviews and assessed by multivariable linear and logistic regression. OCPs were detected in 84.2% (β-HCH), 21.7% (α-HCH), and 19.6% (dicofol) of the population. β-HCH levels were positively related to age, body mass index (BMI), mother’s occupation in agriculture during pregnancy, living in Poniente and Alpujarras, white fish, milk and water consumption, and negatively related to being male, living near to an agricultural area, working ≥10 years in agriculture, and beer consumption. Detectable α-HCH levels were positively related to age, BMI, milk consumption, mother’s occupation in agriculture during pregnancy, and negatively with residence in Poniente and Alpujarras, Granada city, and Granada Metropolitan Area. Residence near to an agricultural area, smoking habit, white fish and water consumption, and living in Poniente and Alpujarras, Granada city and Granada Metropolitan Area were negatively associated with detectable dicofol levels. Our study revealed different bioaccumulation patterns of α, β-HCH and dicofol, probably due to their dissimilar period of use, and emphasize the need for assessing the exposure to frequently overlooked pollutants.

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Section: Discussionsupporting

confidence: 69%

Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Salcedo‐Bellido

Amaya

Pérez-Díaz

et al. 2022

IJERPH

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“…Despite the low blood values, there were significant negative associations between the PCB congeners 99, 138, and 153 and gestational age. Bravo et al found a negative association between HCB and PCB 153 and head circumference in neonates from Siberia [ 7 ]. In our material, we did not detect any association, either positive or negative, concerning levels of POPs and head circumference.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of maternal PCBs and OCPs levels on birth outcomes were assessed by multiple linear regression models. The potential covariates and confounders adjusted for in the regression models were selected based on previous literature [ 7 , 12 ] or on their association with maternal blood POPs and or birth outcomes ( p < 0.05) in this study. Covariates included maternal age (years), parity (para 0, para (1−3), and para (≥4)), body mass index (BMI, kg/m 2 ), residence area (inland/floating area), education (years), occupation (housewife, worker, farmer, teacher, and fishing).…”

Section: Methodsmentioning

confidence: 99%

“…Covariates included maternal age (years), parity (para 0, para (1−3), and para (≥4)), body mass index (BMI, kg/m 2 ), residence area (inland/floating area), education (years), occupation (housewife, worker, farmer, teacher, and fishing). In addition, ponderal index was added into the gestational age regression model, and gestational age was introduced into birth weight, birth length, head circumference, and ponderal index regression models [ 7 ].…”

Section: Methodsmentioning

confidence: 99%

“…The long-term impact of exposure to these pollutants is not fully understood. Of particular interest is the “cocktail effect” on the developing neural systems in fetuses and young children since organochlorines are lipophilic and thus accumulate in fatty tissue [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Serum Concentrations of Selected Organochlorines in Pregnant Women and Associations with Pregnancy Outcomes. A Cross-Sectional Study from Two Rural Settings in Cambodia

Steinholt

Ha³

et al. 2020

IJERPH

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We conducted a cross-sectional study among 194 pregnant women from two low-income settings in Cambodia. The inclusion period lasted from October 2015 through December 2017. Maternal serum samples were analyzed for persistent organic pollutants (POPs). The aim was to study potential effects on birth outcomes. We found low levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCP), except for heptachlors, β-hexachlorocyclohexane (HCH), heptachlor epoxide, and p,p’-DDE. There were few differences between the two study locations. However, the women from the poorest areas had significantly higher concentrations of p,p’-DDE (p < 0.001) and hexachlorobenzene (HCB) (p = 0.002). The maternal factors associated with exposure were parity, age, residential area, and educational level. Despite low maternal levels of polychlorinated biphenyls, we found significant negative associations between the PCB congeners 99 (95% CI: −2.51 to −0.07), 138 (95% CI: −1.28 to −0.32), and 153 (95% CI: −1.06 to −0.05) and gestational age. Further, there were significant negative associations between gestational age, birth length, and maternal levels of o,p’-DDE. Moreover, o,p’-DDD had positive associations with birth weight, and both p,p’-DDD and o,p’-DDE were positively associated with the baby’s ponderal index. The poorest population had higher exposure and less favorable outcomes.

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Residual levels, phase distributions, and human health risks of OCPs in the middle reach of the Huai River, China

Wang,

Wu,

Yuan

2024

Environ Sci Pollut Res

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Drivers of maternal accumulation of organohalogen pollutants in Arctic areas (Chukotka, Russia) and 4,4′-DDT effects on the newborns

Cited by 24 publications

References 60 publications

Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Serum Concentrations of Selected Organochlorines in Pregnant Women and Associations with Pregnancy Outcomes. A Cross-Sectional Study from Two Rural Settings in Cambodia

Residual levels, phase distributions, and human health risks of OCPs in the middle reach of the Huai River, China

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