2021
DOI: 10.1016/j.jns.2021.119452
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Driving motor cortex oscillations modulates bradykinesia in Parkinson's disease

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Cited by 10 publications
(18 citation statements)
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“…Stimulation targeting gamma band activity has been shown to improve motor symptoms in PD by a comparable scale to high-frequency stimulation, while this was not observed for stimulation at theta and beta frequencies [11]. In another study, transcranial alternating current stimulation (tACS) at gamma frequency was observed to increase motor velocity in PD, while tACS at beta frequency saw it decrease [12]. It was hypothesised that entrainment (specifically 1:1 entrainment, as depicted in Figure 1B) of both gamma and beta oscillations would explain this observation by enhancing “prokinetic” and “antikinetic” rhythms, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…Stimulation targeting gamma band activity has been shown to improve motor symptoms in PD by a comparable scale to high-frequency stimulation, while this was not observed for stimulation at theta and beta frequencies [11]. In another study, transcranial alternating current stimulation (tACS) at gamma frequency was observed to increase motor velocity in PD, while tACS at beta frequency saw it decrease [12]. It was hypothesised that entrainment (specifically 1:1 entrainment, as depicted in Figure 1B) of both gamma and beta oscillations would explain this observation by enhancing “prokinetic” and “antikinetic” rhythms, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…In sum, we believe our data advance the understanding of basic mechanisms involved in speech production in health and disease. They also highlight two new dissociable neurophysiological markers of symptom-specific clinical decline in PD, which improve the targeting of non-invasive neuromodulatory therapies in PD 49,51 . Further, the principle of the SDI is generalizable to other neurological and/or psychiatric disorders.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, it remains relatively unclear to what extent these patterns of aberrant neural activity during active speech production under highly controlled experimental conditions relate to the realworld difficulties experienced by patients with PD. Given the key role of rhythmic neural activity in motor and cognitive impairments in patients with PD [46][47][48] , and the proven and future potential for therapeutic interventions based on frequency-specific neurostimulation in this population [49][50][51] , a clearer understanding of the spatio-spectral neural bases of speech intelligibility deficits in PD is essential.…”
mentioning
confidence: 99%
“…The basal ganglia, primary motor cortex (M1), and cerebellum have all been implicated in contributing to bradykinesia in PD suggesting a network-level dysfunction 1 . Recordings of local field potentials (LFPs) in the STN have revealed exaggerated neuronal oscillations and synchrony in the beta frequency band (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) as a marker of pathophysiology of Parkinson's disease, including bradykinesia [2][3][4] . Similarly, reductions in beta power and burst duration with medication and/or DBS are associated with its improvement [5][6][7] .…”
Section: Introductionmentioning
confidence: 99%
“…This heightened synchrony does not exist solely in the basal ganglia, but instead appears to propagate throughout the basal ganglia-thalamo-cortical loop, as evident by simultaneous bilateral STN and subcortical-cortical recordings [8][9][10][11][12][13][14] . Entraining beta within this circuit via transcranial alternate current stimulation over the primary motor cortex has been shown to worsen bradykinesia 15 . Furthermore, the potential network dysfunction contributing to bradykinesia may not be limited only to the contralateral side of the basal ganglia-thalamo-cortical loop.…”
Section: Introductionmentioning
confidence: 99%