Driving the Future of Nuclear Medicine

Herrmann, Ken; Veit-Haibach, Patrick

doi:10.2967/jnumed.119.232264

J Nucl Med

2019

DOI: 10.2967/jnumed.119.232264

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Driving the Future of Nuclear Medicine

Ken Herrmann

Patrick Veit-Haibach

Abstract: All that wants to stay must decay.-Freely adapted from J.W. von Goethe, ''Denn alles muß in Nichts zerfallen, wenn es im Sein beharren will'' Nucl ear medicine thrives by continuous change. Twenty years

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Cited by 9 publications

(1 citation statement)

References 8 publications

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“…We are moving forward from nuclear radiology to nuclear medicine. The emergence of molecular diagnostics and molecular radiotherapies demands changes in training to achieve broader and deeper clinical competence (1,2). We are intimately involved in the management of cancer and neurologic, cardiac, infectious, and inflammatory diseases, among others.…”

mentioning

confidence: 99%

The Standard of Care: From Nuclear Radiology to Nuclear Medicine

Czernin¹

2020

J Nucl Med

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mentioning

confidence: 99%

The Standard of Care: From Nuclear Radiology to Nuclear Medicine

Czernin¹

2020

J Nucl Med

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Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies

et al. 2020

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k-Opioid receptors (KORs) play a predominant role in pain alleviation, itching skin diseases, depression and neurodegenerative disorders such as multiple sclerosis. Therefore, imaging of KOR by a fluorinated PET tracer was envisaged. Two strategies were followed to introduce a F atom into the very potent class of cis,transconfigured perhydroquinoxalines. Whereas the synthesis of fluoroethyltriazole 2 has already been reported, fluoropyrrolidines 14 (1-[2-(3,4-dichlorophenyl)acetyl]-8-[(R)-3-fluoropyrrolidin-1-yl]-perhydroquinoxalines) were prepared by S N 2 substitution of a cyclic sulfuric acid derivative with hydroxypyrrolidine and subsequent transformation of the OH moiety into a F substituent. Fluoropyrrolidines 14 showed similar low-nanomolar KOR affinity and selectivity to the corresponding pyrrolidines, but the corresponding alcohols were slightly less active. In the cAMP and β-arrestin assay, 14b (proton at the 4-position) exhibited similar KOR agonistic activity as U-50,488. The fluoro derivatives 14b and 14c (CO 2 CH 3 at the 4-position) revealed KOR-mediated anti-inflammatory activity as CD11c and the IFN-γ production were reduced significantly in mouse and human dendritic cells. Compounds 14b and 14-c also displayed antiinflammatory and immunomodulatory activity in mouse and human T cells. The PET tracer [ 18 F]-2 was prepared by 1,3-dipolar cycloaddition. In vivo, [ 18 F]-2 did not label KOR due to very fast elimination kinetics. Nucleophilic substitution of a mesylate precursor provided [ 18 F]-14c. Unfortunately, defluorination of [ 18 F]-14c occurred in vivo, which was analyzed in detail by in vitro studies.

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OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer

et al. 2021

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A novel and suitable energy‐dispersive X‐ray fluorescent (EDXRF) device, currently at the prototype stage, the Project OXIRIS (Orthovoltage X‐Ray–Induced Radiation System), is presented for the simultaneous detection and treatment of cancer diseases. Monte Carlo simulation and experimental results of EDXRF signals from a small deep artificial tumor consisting of a solution of gold nanoparticles bio‐targeted and immersed in a tissue‐bioequivalent matrix are presented and compared. Briefly, the device consists of a dynamic orthovoltage X‐ray fluence concentration coupled to confocal with an EDXRF system along with a sample holder for 3D scanning; all integrated and controlled by a dedicated software capable of controlling the whole operation functionalities: the X‐ray source, the rotating arm, the sample holder, and the detection system. The software also includes dedicated subroutines for X‐ray fluorescent spectra processing to correlate K‐lines signal at each acquisition position with the corresponding high atomic number elements' concentration to produce a 3D distribution according to the user‐defined grid. The confocal configuration ensures that the detected signal comes exclusively from the excited volume as defined by the bulk of the focal spot. Hence, the 3D image is achieved by scanning the sample holder through the movement of the sample‐carrier stretcher moved by step motors in the 3 coordinated axes. The feasibility of the proposed methodology and the design of the prototype have been successfully demonstrated experimentally, targeting gold nanoparticles in water‐equivalent phantoms.

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Driving the Future of Nuclear Medicine

Abstract: All that wants to stay must decay.-Freely adapted from J.W. von Goethe, ''Denn alles muß in Nichts zerfallen, wenn es im Sein beharren will'' Nucl ear medicine thrives by continuous change. Twenty years

Cited by 9 publications

References 8 publications

The Standard of Care: From Nuclear Radiology to Nuclear Medicine

The Standard of Care: From Nuclear Radiology to Nuclear Medicine

Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies

OXIRIS project: Development of a new XRF device for the simultaneous detection and treatment of cancer

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