“…These last two patterns increase the risks, enhance the effects of some substances on others, interfere with diagnosis and make treatment more difficult [ 29 ]. A previous intervention in 3882 Spanish adolescents pointed out that, in the short term, the consumption of more than one substance led to a higher probability of consuming other illegal substances, risky or abusive consumption of alcohol (binge drinking), traffic accidents, injuries, risky sexual relations with a greater probability of sexually transmitted diseases, fights, problematic use of the Internet or cyberbullying [ 31 ], criminal behavior and other acts of violence [ 32 , 33 , 34 ]. In terms of medium- and long-term consequences, it is associated with physical problems, low cognitive performance, depression and suicide.…”