2024
DOI: 10.4070/kcj.2023.0197
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Dronedarone Attenuates Ang II-Induced Myocardial Hypertrophy Through Regulating SIRT1/FOXO3/PKIA Axis

Cheng Chen,
Song Hu,
Heng-Jing Hu
et al.

Abstract: Author's summary Dronedarone can attenuate left ventricular hypertrophy of mice. However, the underlying mechanism of dronedarone in myocardial hypertrophy (MH) is unknown. Our results indicated that dronedarone increased sirtuin 1 (SIRT1) expression. Further, SIRT1 mediated deacetylation of forkhead box O3 (FOXO3) to upregulate FOXO3 expression and FOXO3 interacted with protein kinase inhibitor alpha (PKIA) promoter to elevate PKIA expression. Dronedarone suppressed angiotensin II-induced cell hype… Show more

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