Drop-of-blood acoustic tweezing technique for integrative turbidimetric and elastometric measurement of blood coagulation

Luo, Daishen; Chelales, Erika; Beard, Millicent M; Kasireddy, Nithya; Khismatullin, Damir B.

doi:10.1007/s00216-021-03278-8

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…The change in elasticity of coagulating blood plasma is identical to the mechanical tweezograph reported in ref. 36. It should be noted that the sample drop elasticity is proportional to the drop radius squared, according to eqn (4).…”

Section: Resultsmentioning

confidence: 99%

“…The quasi-static method, in which sample deformation is induced by slowly varying acoustic pressure, is highly sensitive to sample elasticity changes and has been shown to be effective for sample firmness measurement during coagulation or polymerization. 35,36 In the oscillatory method, the sample deformation (shape oscillation) is achieved by amplitude modulation of the input pressure. The sample rheological properties are then measured from either the free decay response 37,38 or the forced response.…”

Section: Introductionmentioning

confidence: 99%

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Drop-of-sample rheometry of biological fluids by noncontact acoustic tweezing spectroscopy

2022

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Drop-of-sample rheometry of biological fluids by noncontact acoustic tweezing spectroscopy

2022

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“…Luo et al [ 125 ] introduced the integrated quasi-static acoustic tweezing thromboelastometry (i-QATT™) method of analyzing blood coagulation in a single drop of blood. Using acoustic radiation to levitate and shape the drop, it measured coagulation-related changes rapidly and accurately within 10 min.…”

Section: Other Special Techniques For Platelet Analysismentioning

confidence: 99%

Advances in Platelet-Dysfunction Diagnostic Technologies

Yoon,

Han,

Jeon

2024

Biomolecules

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The crucial role of platelets in hemostasis and their broad implications under various physiological conditions underscore the importance of accurate platelet-function testing. Platelets are key to clotting blood and healing wounds. Therefore, accurate diagnosis and management of platelet disorders are vital for patient care. This review outlines the significant advancements in platelet-function testing technologies, focusing on their working principles and the shift from traditional diagnostic methods to more innovative approaches. These improvements have deepened our understanding of platelet-related disorders and ushered in personalized treatment options. Despite challenges such as interpretation of complex data and the costs of new technologies, the potential for artificial-intelligence integration and the creation of wearable monitoring devices offers exciting future possibilities. This review underscores how these technological advances have enhanced the landscape of precision medicine and provided better diagnostic and treatment options for platelet-function disorders.

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Whole blood PT/aPTT assay based on non-contact drop-of-sample acoustic tweezing spectroscopy

Kasireddy,

Luo,

Khismatullin

2023

Anal Bioanal Chem

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Drop-of-blood acoustic tweezing technique for integrative turbidimetric and elastometric measurement of blood coagulation

Cited by 4 publications

References 39 publications

Drop-of-sample rheometry of biological fluids by noncontact acoustic tweezing spectroscopy

Drop-of-sample rheometry of biological fluids by noncontact acoustic tweezing spectroscopy

Advances in Platelet-Dysfunction Diagnostic Technologies

Whole blood PT/aPTT assay based on non-contact drop-of-sample acoustic tweezing spectroscopy

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