Drop Size Stability Assessment of Fluorocarbon Emulsions

Krafft, Marie Pierre; Postel, M.; Riess, Jean G.; Ni, Yajuan; Pelura, Tim J.; Hanna, G K; Song, Dian

doi:10.3109/10731199209119732

Cited by 6 publications

(11 citation statements)

References 3 publications

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“…A fluorocarbon colloid-particle suspension and a suspension of rigid microspheres were used in the experiments. The colloid material [ZY-15017 (perfluorooctyl bromide suspended in egg yolk phospholipid); Alliance Pharmaceuticals, San Diego, CA] is a fluorocarbon emulsion which has 60% wt/vol and contains particles (1-µm average diameter) covered with a phospholipid membrane (16,17,21). Its density is 1.92 g/ml, and the original concentration of particles is 1.0 ϫ 10 22 /ml.…”

Section: Methodsmentioning

confidence: 99%

Transport of colloidal particles in lymphatics and vasculature after subcutaneous injection

Higuchi

Fokin²,

Masters³

et al. 1999

Journal of Applied Physiology

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This study was designed to determine the transport of subcutaneously injected viral-size colloid particles into the lymph and the vascular system in the hind leg of the dog. Transport of two colloid particles, with average size approximately 1 and 0.41 microm, respectively, and with and without leg rotation, was tested. Leg rotation serves to enhance the lymph flow rates. The right femoral vein, lymph vessel, and left femoral artery were cannulated while the animal was under anesthesia, and samples were collected at regular intervals after subcutaneous injection of the particles at the right knee level. The number of particles in the samples were counted under fluorescence microscopy by using a hemocytometer. With and without leg rotation, both particle sets were rapidly taken up into the venous blood and into the lymph fluid. The number of particles carried away from the injection site within the first 5 min was <5% of the injected pool. Particles were also seen in arterial blood samples; this suggests reflow and a prolonged residence time in the blood. These results show that particles the size of viruses are rapidly taken up into the lymphatics and blood vessels after subcutaneous deposition.

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Section: Methodsmentioning

confidence: 99%

Transport of colloidal particles in lymphatics and vasculature after subcutaneous injection

Higuchi

Fokin²,

Masters³

et al. 1999

Journal of Applied Physiology

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“…116 time, the capabilities of fluorinated oils to solubilise gases 118 is a key for cell survival. Systems based on fluorocarbon oils are used in clinical tests as artificial blood substitutes, mostly for their interesting properties regarding gas exchange [119][120][121][122] . A microfluidic example of the use of the high solubility of respiratory gases in fluorinated oils is given in Abbyab et al 109,123 .…”

Section: Short Chainsmentioning

confidence: 99%

Surfactants in droplet-based microfluidics

2012

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Surfactants are an essential part of the droplet-based microfluidic technology. They are involved in the stabilization of droplet interfaces, in the biocompatibility of the system and in the process of molecular exchange between droplets. The recent progress in the applications of droplet-based microfluidics has been made possible by the development of new molecules and their characterizations. In this review, the role of the surfactant in droplet-based microfluidics is discussed with an emphasis on the new molecules developed specifically to overcome the limitations of 'standard' surfactants. Emulsion properties and interfacial rheology of surfactant-laden layers strongly determine the overall capabilities of the technology. Dynamic properties of droplets, interfaces and emulsions are therefore very important to be characterized, understood and controlled. In this respect, microfluidic systems themselves appear to be very powerful tools for the study of surfactant dynamics at the time- and length-scale relevant to the corresponding microfluidic applications. More generally, microfluidic systems are becoming a new type of experimental platform for the study of the dynamics of interfaces in complex systems.

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“…For droplet-based screening applications, these properties are highly valuable. The low solubility of organic molecules in fluorous fluids results in restricted cross-talk between emulsion droplets [25] by a reduction of the partitioning coefficient while the high solubility of respiratory gases is a key for cell survival in droplets [75,76,77,78]. Furthermore, while conventional hydrocarbon compounds may swell the microfluidic core material PDMS (PolyDiMethylSiloxane), leading to device delamination or channel deformation, fluorinated compounds are highly compatible with PDMS [79].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Stabilisers for water-in-fluorinated-oil dispersions: Key properties for microfluidic applications

Gruner

Riechers

Orellana

et al. 2015

Current Opinion in Colloid & Interface Science

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Droplet-based microfluidics appears as a key emerging technology for the miniaturization and automation of biochemical assays. In terms of technology, it stands on two basic pillars: microfluidic devices on the one hand and emulsions on the other hand. Huge progress has been made on large scale integration of devices and batch production of devices. The limiting factor for a full application of the technology is actually not device development, but rather the robust control of emulsion formulations to be used in these devices. We here review the basic problems related to emulsions relevant for microfluidic applications and open up on new promising applications for these systems

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Drop Size Stability Assessment of Fluorocarbon Emulsions

Cited by 6 publications

References 3 publications

Transport of colloidal particles in lymphatics and vasculature after subcutaneous injection

Transport of colloidal particles in lymphatics and vasculature after subcutaneous injection

Surfactants in droplet-based microfluidics

Stabilisers for water-in-fluorinated-oil dispersions: Key properties for microfluidic applications

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