Droplet and Particle Generation on Centrifugal Microfluidic Platforms: A Review

Azimi-Boulali, Javid; Madadelahi, Masoud; Madou, Marc; Martínez-Chapa, Sergio O.

doi:10.3390/mi11060603

Cited by 35 publications

(27 citation statements)

References 122 publications

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“…Again, Liu et al made use of a step after a flow-focusing nozzle in their microfluidic device for external gelation of alginate droplets 18 . However, in almost all of these researches, either those utilizing a combined configuration or those using a single geometry, the desired droplet generation process (production of spherical droplets in a dripping mode) has been confined to a limited range of flow rates 19 .…”

Section: Introductionmentioning

confidence: 99%

Microfluidic on-chip production of microgels using combined geometries

Shieh

Saadatmand

Eskandari

et al. 2021

Sci Rep

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Microfluidic on-chip production of microgels using external gelation can serve numerous applications that involve encapsulation of sensitive cargos. Nevertheless, on-chip production of microgels in microfluidic devices can be challenging due to problems induced by the rapid increase in precursor solution viscosity like clogging. Here, a novel design incorporating a step, which includes a sudden increase in cross-sectional area, before a flow-focusing nozzle was proposed for microfluidic droplet generators. Besides, a shielding oil phase was utilized to avoid the occurrence of emulsification and gelation stages simultaneously. The step which was located before the flow-focusing nozzle facilitated the full shielding of the dispersed phase due to 3-dimensional fluid flow in this geometry. The results showed that the microfluidic device was capable of generating highly monodispersed spherical droplets (CV < 2% for step and CV < 5% for flow-focusing nozzle) with an average diameter in the range of 90–190 μm, both in step and flow-focusing nozzle. Moreover, it was proved that the device could adequately create a shelter for the dispersed phase regardless of the droplet formation locus. The ability of this microfluidic device in the production of microgels was validated by creating alginate microgels (with an average diameter of ~ 100 μm) through an external gelation process with on-chip calcium chloride emulsion in mineral oil.

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Section: Introductionmentioning

confidence: 99%

Microfluidic on-chip production of microgels using combined geometries

Shieh

Saadatmand

Eskandari

et al. 2021

Sci Rep

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show abstract

“…These LUOs are overwhelmingly processed in a batch-wise, rather than a continuous-flow fashion, by transiently sealing their fluidic exit with a normally-closed valve, thus intermittently stopping the flow while continuing rotation within certain boundaries, e.g., for vigorous agitation of the liquid sample. These centrifugal LUOs and their linked downstream detection techniques have been comprehensive reviewed elsewhere [24][25][26][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67].…”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Ducrée¹

2021

Preprint

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Current, application-driven trends towards larger-scale integration (LSI) of microfluidic systems for comprehensive assay automation and multiplexing pose significant technological and economical challenges to developers. By virtue of their intrinsic capability for powerful sample preparation, centrifugal systems have attracted significant interest in academia and business since the early 1990s. This review models common, rotationally controlled valving schemes at the heart of such “Lab-on-a-Disc” (LoaD) platforms to predict critical spin rates and reliability of flow control mainly based on geometries, location and liquid volumes to be processed, and their experimental tolerances. In absence of larger-scale manufacturing facilities during product development, the method presented here facilitates the provision of efficient simulation tools for virtual prototyping and characterization to greatly expedite design optimization according to key performance metrics. This virtual in silico approach thus significantly accelerates, de-risks and lowers costs along the critical advancement from idea, fluidic testing, bioanalytical validation and scale-up to commercial mass manufacture.

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“…This paper introduces strategies to incorporate anti-counterfeit technologies into commercially already well-established centrifugal microfluidic platform. These "Lab-on-a-Disc" (LoaD) systems, which have been successfully developed in industry [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] and academia [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] since the early 1990s, pursue a conceptually simple mechanism for the transport and conditioning of liquid samples and reagents in so-called laboratory unit operations (LUOs) through the artificial gravity field created by a conventional spindle motor [52][53][54][55][56][57][58][59][60][61][62][63][64]…”

Section: Introductionmentioning

confidence: 99%

Anti-Counterfeit Technologies for Microfluidic “Lab-on-a-Disc” Systems

Ducrée¹

2021

Preprint

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Non-genuine medical products, including diagnostic devices, have become a lucrative business for fraudsters, causing significant damage to revenues and reputation of companies, as well as posing a significant risk to the health of people and societies. Along a “digital twin” representing centrifugal microfluidic flow control on exemplary “Lab-on-a-Disc” (LoaD) systems, a novel, two-pronged strategy to safeguard miniaturized point-of-care devices by means of secret features and manufacturing challenges is outlined; such “hardware encryption” is flexibly programmed for each chip during production, and deciphered from a secure, local or online database at the time of use. This way, unlicensed copying may be efficiently deterred by an unfavourable economy-of-scale, even in absence of legal prosecution.

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Droplet and Particle Generation on Centrifugal Microfluidic Platforms: A Review

Cited by 35 publications

References 122 publications

Microfluidic on-chip production of microgels using combined geometries

Microfluidic on-chip production of microgels using combined geometries

Systematic Review of Centrifugal Valving Based on Digital Twin Modelling towards Highly Integrated Lab-on-a-Disc Systems

Anti-Counterfeit Technologies for Microfluidic “Lab-on-a-Disc” Systems

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