Droplet-Based Microfluidics: Formation, Detection and Analytical Characterization

Abstract

Droplet generationDroplets are generally formed with two different techniques known as T-junction [5] and flow focussing [6]. In the T-junction technique, dispersed phase flow intersects perpendicularly with the carrier phase flow. The tip of the dispersed phase enters the carrier phase as the flow continues and elongates along the channel due to the interfacial tension and shear stress present at the interface. Finally, the interfacial tension increases and breaks the

Highly sensitive absorbance measurement using droplet microfluidics integrated with an oil extraction and long pathlength detection flow cell

“…Chemicals mix rapidly in the droplet due to chaotic advection ( Gan et al, 2023 ; Zhang et al, 2023 ), while mixing in the laminar flow of single-phase microfluidics is mainly achieved by relatively slow diffusion process ( Ulkir et al, 2021 ). The droplet flow also reduces Taylor dispersion that is present in the single-phase flows ( Hassan et al, 2019 ; Elvira et al, 2022 ). Therefore, droplet microfluidics enables less cross-contamination between samples and faster response for biochemical analysis, in addition to reduced reagent consumptions ( Basova and Foret, 2015 ; Sun et al, 2020 ).…”