Droplet-based synthetic method using microflow focusing and droplet fusion

Liu, Kan; Ding, Huijiang; Chen, Yong; Zhao, Xingzhong

doi:10.1007/s10404-006-0121-8

Cited by 83 publications

(62 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tanthapanichakoon et al (2006) reported that axial arrangement of droplet constituents enhances mixing and it can be attributed to the reduction of the striation length between reactant segment by interlayering. Similar results for enhanced mixing due to axial arrangement (in-line droplet fusion) have been reported by Liu et al (2007) and Frenz et al (2008). Therefore, it can be stated that axial arrangement of droplet constituents in this merging design leads to enhanced mixing.…”

Section: Enhanced Mixingsupporting

confidence: 85%

Reliable addition of reagents into microfluidic droplets

Sivasamy

Chim

Wong

et al. 2009

Microfluid Nanofluid

View full text Add to dashboard Cite

This article reports a design that reliably adds reagents into droplets by exploiting the physics of fluid flow at a T-junction in the microchannel. An expanded section right after the T-junction enhances merging of a stream with a droplet, eliminates the drawbacks such as extra droplet formation and long mixing time. The expanded section reduces the pressure buildup at the T-junction and minimizes the tendency to form extra droplets; plays the role in creating low Laplace pressure jump across the interface of the droplet forming from the T-junction which reduces the probability of forming extra droplet in the merging process; provides space for droplet coalescence if there is an extra droplet due to droplet break-up before merging. In this design, after merging, the reactants are in axial arrangement inside the droplets which lead to faster mixing. Reliable addition of reagent to the droplets happens for the combination of flow rates in a broad range from 25 to 250 ll/h, for both DI water (Q DI ) and fluorescent (Q fluo ) streams.

show abstract

Section: Enhanced Mixingsupporting

confidence: 85%

Reliable addition of reagents into microfluidic droplets

Sivasamy

Chim

Wong

et al. 2009

Microfluid Nanofluid

View full text Add to dashboard Cite

show abstract

“…To confirm the concentration of blue dye inside the mixed droplet, droplet teams with different VR were provided by adjusting the flow rates of oil and reagents. Then, they were examined by the API method, which were consistent with VR basically (Figure 4c) and the slight deviation is on account of the light curving over the boundary of droplets and software measurement error [25]. …”

Section: Droplet Generation and Fusionmentioning

confidence: 87%

“…The oil phase was introduced into the chip through the two oil inlets, while DI water was injected into inlet A. Then the diluted blue dye was cut into droplets by shear forces from oil phase at the two flow-focusing junctions [25,26]. By precisely controlling the flow rates of continuous phase and dispersed phase, blue dye droplets were arrayed between the DI water droplets in downstream fusing channel.…”

Section: On-chip Operationmentioning

confidence: 99%

A Concentration-Controllable Microfluidic Droplet Mixer for Mercury Ion Detection

et al. 2015

Self Cite

View full text Add to dashboard Cite

Abstract:A microfluidic droplet mixer is developed for rapid detection of Hg(II) ions. Reagent concentration and droplets can be precisely controlled by adjusting the flow rates of different fluid phases. By selecting suitable flow rates of the oil phase, probe phase and sample phase, probe droplets and sample droplets can be matched and merged in pairs and subsequently well-mixed in the poly (dimethylsiloxane) (PDMS) channels. The fluorescence enhancement probe (Rhodamine B mixed with gold nanoparticles) encapsulated in droplets can react with Hg(II) ions. The Hg(II) ion concentration in the sample droplets is adjusted from about 0 to 1000 nM through fluid regulation to simulate possible various contaminative water samples. The intensity of the emission fluorescence is sensitive to Hg(II) ions (increases as the Hg(II) ion concentration increases). Through the analysis of the acquired fluorescence images, the concentration of Hg(II) ions can be precisely detected. With the advantages of less time, cost consumption and easier manipulations, this device would have a great potential in micro-scale sample assays and real-time chemical reaction studies.

show abstract

“…Besides geometry-based pressure control for droplet mixing [75], merging [76,77] and sorting [78,79], many active control methods have been realized recently, such as hydrostatic pressure [80], temperature gradient [81], thermal expansion [82], optical approaches [83][84][85], magnetic field [86] and electrical control [87][88][89], including electrostactic [90], electrokinetic effect [91], dielectrophoresis [92] and electrowetting [93][94][95][96][97][98]. Among them, electrowetting on dielectric [99][100][101] has been proved to be very effective for cutting, merging, creating and transporting liquid droplets, while its disadvantage is that many electrodes should be fabricated with metallic thin film, causing droplet moving and device fabrication complex, while, with GERF, one can control and manipulate the droplets by much fewer electrodes [102,103].…”

Section: Manipulation Of Dropletsmentioning

confidence: 99%

Manipulation of microfluidic droplets by electrorheological fluid

2009

View full text Add to dashboard Cite

Microfluidics, especially droplet microfluidics, attracts more and more researchers from diverse fields, because it requires fewer materials and less time, produces less waste and has the potential of highly integrated and computer-controlled reaction processes for chemistry and biology. Electrorheological fluid, especially giant electrorheological fluid (GERF), which is considered as a kind of smart material, has been applied to the microfluidic systems to achieve active and precise control of fluid by electrical signal. In this review article, we will introduce recent results of microfluidic droplet manipulation, GERF and some pertinent achievements by introducing GERF into microfluidic system: digital generation, manipulation of "smart droplets" and droplet manipulation by GERF. Once it is combined with real-time detection, integrated chip with multiple functions can be realized.

show abstract

Droplet-based synthetic method using microflow focusing and droplet fusion

Cited by 83 publications

References 15 publications

Reliable addition of reagents into microfluidic droplets

Reliable addition of reagents into microfluidic droplets

A Concentration-Controllable Microfluidic Droplet Mixer for Mercury Ion Detection

Manipulation of microfluidic droplets by electrorheological fluid

Contact Info

Product

Resources

About