Droplet impact dynamics is an interfacial phenomenon that is shown everywhere in nature and is the underlying of numerous technological applications including bio-printing, tissue engineering, pharmaceuticals, fight against COVID-19 pandemic, smart biomaterials, and flexible electronics. Over the last decade, expeditious advancement of novel functional interfacial surfaces, high-speed visualization, nanoscience, nanotechnology, machine learning, and computational power, as well as the connection of flow physics with interfacial science, have contributed to enhancing the understanding of relevant complex physical phenomena. Droplet, upon impacting onto substrates, can deposit, spread, bounce, and splash. Features of droplet impact physics and surface wettability necessitate elaborate solid–liquid interactions. Given the significance of droplet impact physics for healthcare and electronics, it is recommended for the scientific community to direct research studies to profound the understanding of such complex physics. Therefore, this Review initially focuses on liquid–solid interfacial science. Second, droplet impact physics on numerous solid surfaces was discussed. Substrates with various wettability and physical features were considered: hydrophilic, hydrophobic, superhydrophobic, smooth, rough, and flexible elastic surfaces. Furthermore, numerous advancements of droplet impact on solid surfaces related to advanced technologies and challenges including printed electronics, smart biomaterials, tissue engineering, machine learning, and COVID-19 pandemic were reviewed. Finally, this Review outlines future perspectives and research directions in complex droplet impact physics.