Droplet release in a highly parallel, pressure driven nanoliter dispenser

Gutmann, Oliver; Niekrawietz, Remigius; Steinert, Chris P.; Sandmaier, H.; Messner, S.; Heij, Bas de; Daub, Martina; Zengerle, Roland

doi:10.1109/sensor.2003.1215329

Cited by 17 publications

(14 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Laser-induced forward transfer (LIFT) is a direct-write non-contact method, which offers an interesting and versatile alternative to conventional arraying techniques, since it does not require the use of expensive photolithographic equipment [20], and it does not suffer from clogging and contamination problems, as pin deposition and ink-jet printing do [21][22][23][24][25]. It is the long transfer distances [18,19], the precise and high focusing ability of lasers and the laser directionality [11], which gives flexibility to the LIFT method.…”

Section: Introductionmentioning

confidence: 99%

Development of peptide-based patterns by laser transfer

Dinca

Kasotakis

Catherine

et al. 2007

Applied Surface Science

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Development of peptide-based patterns by laser transfer

Dinca

Kasotakis

Catherine

et al. 2007

Applied Surface Science

View full text Add to dashboard Cite

“…Various liquid handling techniques for sub-nanoliter liquid have been reported for a lab-on-a-chip [10]. However, there are still many technical problems to integrate various microfluidic components into a single chip, especially in the input and output of liquid samples [11].…”

Section: Introductionmentioning

confidence: 99%

Film transfer and bonding techniques for covering single-chip ejector array with microchannels and reservoirs

Kwon

Kim

2005

J. Microelectromech. Syst.

View full text Add to dashboard Cite

This paper describes a novel covering technique for an MEMS ejector array that is integrated with liquid reservoirs and microchannels on a single chip. The covering technique is based on wicking of a low viscous epoxy through the gap between the ejector wafer and a plate containing a parylene film, and allows the integrated ejector array to be fully covered by the parylene film with excellent uniformity, repeatability and yield. The technique is batch-processible and is suitable to cover many microfluidic systems with a thin film. The parylene film is tightly attached to the ejector array chip (with excellent bonding strength owing to the epoxy), so that liquid is automatically brought into the ejectors from the reservoirs through the microchannels (due to capillary force), as the ejectors shoot out liquid droplets. This automatic liquid supply makes the liquid level (in the ejector) be maintained constant throughout the entire ejection process until more than 90% of the liquid stored in the reservoir is delivered to the ejector through the microchannel. This paper describes also a number of other covering methods that we have experimentally tried, and compares those with the new covering technique.[1459]Index Terms-Acoustic droplet ejector, enclosed microchannels and reservoirs, epoxy wicking, film cover, integrated ejector array, microfluidic systems, parylene bonding.

show abstract

“…There have been many methods developed for protein micro array generation in the past ten years, such as photo 0-7803-9315-5/05/$20.00 ©2005 IEEE 757 lithography [5,6], micro-needle array [7,8], ink jet technology [9,10], electro spray [11,12], laser ejection [13] and micro contact printing [14][15][16][17], etc. Photolithography methods may pose biocompatible issue, and cannot be easily applied to many different types of proteins on a chip at one time.…”

Section: Introductionmentioning

confidence: 99%

Characterization of simultaneous protein microarray formation by discrete micro stamper on surfaces of different wettabilities

Tseng

et al. 2005

2005 IEEE International Conference on Robotics and Biomimetics - ROBIO

View full text Add to dashboard Cite

Rapid and parallel protein micro/nano array formation provides a powerful tool for protein chip fabrication and protein preservation. This paper presents the characterization of surface tension and viscosity effect on the formation of nano-Iiter droplet array by a novel instant micro stamper, which can simultaneously immobilize hundreds of proteins on a chip. Besides, capillary force is the major driving mechanism of the micro stamper, flowing protein solutions through the chip channel for array-registration and droplet-size control. Three important properties have been characterized in this paper, including uniformity and repeatability of parallel printing process, surface wettability and solution viscosity effect on micro droplet size, and the dynamic sequence of micro droplet formation. First, experiment results demonstrated the uniformity and repeatability of the parallel stamping process for protein micro arrays from area to area and chip to chip. Second, the effects of surface wettability of bioassay chips and solution viscosity on droplet size variation have been investigated in detail by experiments and simulations. Both simulation and experiment results demonstrate that the spot size increases with the increasing of the surface wettability and the decreasing of the solution viscosity, and they showed similar tends. Furthermore, the dynamic process of droplet formation has been observed and analyzed by high-speed images, demonstrating that the foot print reduction rate, formation time, and necking of the printed micro droplet are lower on the more hydrophobic surface. This is dueto the rapid shrinkage of droplet foot print area on hydrophobic surface, resulting in smaller droplet formation. As a result, the droplet size can shrink to 50% or 70%, when the contact angle of the bioassay chip surface increases from 30° to 80°, or solution viscosity varies from 1.02 to 10.08 cp, respectively.

show abstract

Droplet release in a highly parallel, pressure driven nanoliter dispenser

Cited by 17 publications

References 3 publications

Development of peptide-based patterns by laser transfer

Development of peptide-based patterns by laser transfer

Film transfer and bonding techniques for covering single-chip ejector array with microchannels and reservoirs

Characterization of simultaneous protein microarray formation by discrete micro stamper on surfaces of different wettabilities

Contact Info

Product

Resources

About