Drosophila <i>sticky/citron kinase</i> Is a Regulator of Cell-Cycle Progression, Genetically Interacts With <i>Argonaute 1</i> and Modulates Epigenetic Gene Silencing

Sweeney, Sarah; Campbell, Paula; Bosco, Giovanni

doi:10.1534/genetics.107.082511

Cited by 11 publications

(15 citation statements)

References 80 publications

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“…Last, there is evidence that CIT-K has other roles besides in cell division. In addition to its recently described role in DNA damage (Bianchi et al, 2017), CIT-K has also been proposed to function in virus budding, organization of the Golgi complex and epigenetic gene silencing (Camera et al, 2003;Ding et al, 2016;Loomis et al, 2006;Sweeney et al, 2008) but, as yet, there are no major insights into its mechanisms of action in these processes.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Citron kinase – renaissance of a neglected mitotic kinase

D’Avino

2017

Journal of Cell Science

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Cell division controls the faithful segregation of genomic and cytoplasmic materials between the two nascent daughter cells. Members of the Aurora, Polo and cyclin-dependent (Cdk) kinase families are known to regulate multiple events throughout cell division, whereas another kinase, citron kinase (CIT-K), for a long time has been considered to function solely during cytokinesis, the last phase of cell division. CIT-K was originally proposed to regulate the ingression of the cleavage furrow that forms at the equatorial cortex of the dividing cell after chromosome segregation. However, studies in the last decade have clarified that this kinase is, instead, required for the organization of the midbody in late cytokinesis, and also revealed novel functions of CIT-K earlier in mitosis and in DNA damage control. Moreover, CIT-K mutations have recently been linked to the development of human microcephaly, and CIT-K has been identified as a potential target in cancer therapy. In this Commentary, I describe and re-evaluate the functions and regulation of CIT-K during cell division and its involvement in human disease. Finally, I offer my perspectives on the open questions and future challenges that are necessary to address, in order to fully understand this important and yet unjustly neglected mitotic kinase.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Citron kinase – renaissance of a neglected mitotic kinase

D’Avino

2017

Journal of Cell Science

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“…These amino acids are added to the structural maintenance of chromosome (SMC) domain, which could alter the nuclear function of CitK; this has been reported in drosophila where its homolog (called sticky) is required for heterochromatin-mediated gene silencing through HP1 localization and H3-K9 methylation. 28…”

Section: Role Of Alternative Splicing In Citron Kinase Expressionmentioning

confidence: 99%

Loss of Citron Kinase Affects a Subset of Progenitor Cells That Alters Late but Not Early Neurogenesis in the Developing Rat Retina

Karunakaran¹,

Chhaya²,

Lemoine³

et al. 2015

Investigative Ophthalmology & Visual Science

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“…The strongest match is to the coiled-coil of Sticky, the Drosophila citron kinase (Sweeney et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

yuri gagarinis required for actin, tubulin and basal body functions inDrosophilaspermatogenesis

Texada

Simonette

Johnson

et al. 2008

Journal of Cell Science

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A unique feature of the genus Drosophila is the formation of unusually long sperm tails. Sperm lengths of millimeters are common within this group, with the 1.8 mm sperm of D. melanogaster being fairly typical. This marked expansion in sperm length reflects an unusual aspect of spermatogenesis in these organisms: in contrast to other species in which an intraflagellar transport system is used for growth of the sperm flagellum (Scholey, 2006), Drosophila sperm axonemes are assembled in syncytial cysts by a mechanism that does not require, and is not limited by, this system (Han et al., 2003;Sarpal et al., 2003). This unusual sperm axoneme development and the resulting expansion of sperm tail length have led to distinctive features of spermatogenesis not found in other species. In D. bifurca, a special 'sperm roller' has evolved to package its 6-centimeter-long gametes (Joly et al., 2003). In D. melanogaster, a highly evolved individualization process that generates 64 individual sperm from an elongate cyst containing 64 syncytial spermatids has been identified and studied (Noguchi and Miller, 2003;Tokuyasu et al., 1972a). The distinctive molecular mechanisms needed for this process include a motile filamentous actin system (the investment, or actin, cones) that traverses the entire length of the sperm tails, removing excess cytoplasm and investing each sperm in its own plasma membrane. A specialized microtubulerich structure (the dense complex) is also associated with the sperm nuclei and functions to position the basal body and also possibly to strengthen the nuclei as they undergo extreme condensation (A. D. Tates, Cytodifferentiation during spermatogenesis in Drosophila melanogaster, PhD thesis, Rijksuniversiteit Leiden, The Netherlands, 1971) (Tokuyasu, 1974).We have identified a locus, yuri gagarin (yuri), that we show here has multiple roles in the generation of elongate individualized sperm. The gene is only highly conserved in the genus Drosophila, suggesting specialized roles in these organisms. Interestingly, yuri was initially identified through its function in another specialized organ system of insects and arthropods: the chordotonal organs. These are complex mechanosensory structures with roles in proprioception and graviperception. The first mutation at the locus, yuri c263 , was identified in a screen for mutants affecting gravitaxis. Altered gravitaxis was shown to result from perturbed expression of yuri in subsets of chordotonal neurons (Armstrong et al., 2006). The molecular functions of the locus identified here suggest that yuri mediates specialized actin-and microtubule-related activities in Drosophila tissues. ResultsThe yuri locus in D. melanogaster and other Drosophilids In addition to the cDNA (GH14032) encoding a ~30 kDa protein that we used previously (Armstrong et al., 2006), we identified 11 further yuri ESTs/cDNAs from adult testis, ovary, S2 cells and embryos through FlyBase. Sequencing of these new cDNAs established that three major transcript classes are generated from yuri (Fig...

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Drosophila sticky/citron kinase Is a Regulator of Cell-Cycle Progression, Genetically Interacts With Argonaute 1 and Modulates Epigenetic Gene Silencing

Cited by 11 publications

References 80 publications

Citron kinase – renaissance of a neglected mitotic kinase

Citron kinase – renaissance of a neglected mitotic kinase

Loss of Citron Kinase Affects a Subset of Progenitor Cells That Alters Late but Not Early Neurogenesis in the Developing Rat Retina

yuri gagarinis required for actin, tubulin and basal body functions inDrosophilaspermatogenesis

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