Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves

Restrepo, Simon; Basler, Konrad

doi:10.1038/ncomms12450

Cited by 51 publications

(80 citation statements)

References 37 publications

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“…Ca 2+ is a second messenger, and Ca 2+ signaling networks often exhibit a “bow‐tie” structure in that the integrated effect of many inputs is governed by a small number of molecules in the calcium pathway, and they affect many outputs (Brodskiy & Zartman, ), similar to the way that many growth‐affecting factors impinge upon the Hippo kinase cascade. Like Hippo, growth and mechanical signals both affect Ca 2+ (Antunes, Pereira, Cordeiro, Almeida, & Jacinto, ; Balaji et al, ; Brodskiy et al, ; Narciso et al, ; Narciso, Contento, Storey, Hoelzle, & Zartman, ; Restrepo & Basler, ). Ca 2+ signaling in the wing disk exhibits a rich variety of dynamical behaviors.…”

Section: Biochemical Regulation Of Growth and Patterningmentioning

confidence: 99%

Growth control in the Drosophila wing disk

Gou

Stotsky

Othmer

2020

WIREs Mechanisms of Disease

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The regulation of size and shape is a fundamental requirement of biological development and has been a subject of scientific study for centuries, but we still lack an understanding of how organisms know when to stop growing. Imaginal wing disks of the fruit fly Drosophila melanogaster, which are precursors of the adult wings, are an archetypal tissue for studying growth control. The growth of the disks is dependent on many inter‐ and intra‐organ factors such as morphogens, mechanical forces, nutrient levels, and hormones that influence gene expression and cell growth. Extracellular signals are transduced into gene‐control signals via complex signal transduction networks, and since cells typically receive many different signals, a mechanism for integrating the signals is needed. Our understanding of the effect of morphogens on tissue‐level growth regulation via individual pathways has increased significantly in the last half century, but our understanding of how multiple biochemical and mechanical signals are integrated to determine whether or not a cell decides to divide is still rudimentary. Numerous fundamental questions are involved in understanding the decision‐making process, and here we review the major biochemical and mechanical pathways involved in disk development with a view toward providing a basis for beginning to understand how multiple signals can be integrated at the cell level, and how this translates into growth control at the level of the imaginal disk. This article is categorized under: Analytical and Computational Methods > Computational Methods Biological Mechanisms > Cell Signaling Models of Systems Properties and Processes > Cellular Models

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Section: Biochemical Regulation Of Growth and Patterningmentioning

confidence: 99%

Growth control in the Drosophila wing disk

Gou

Stotsky

Othmer

2020

WIREs Mechanisms of Disease

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“…In embryonic wounds, the NADPH oxidase DUOX, which acts as a source of H 2 O 2 , is activated by calcium, and Ca 2+ flashes have been found upon damage [43]. Intercellular Ca 2+ waves, propagated via gap junctions are triggered by injury to imaginal discs [44, 45]. …”

Section: Wound Healing and Early Responses To Tissue Damagementioning

confidence: 99%

Imaginal disc regeneration takes flight

Hariharan

Serras

2017

Current Opinion in Cell Biology

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Drosophila imaginal discs, the larval precursors of adult structures such as the wing and leg, are capable of regenerating after damage. During the course of regeneration, discs can sometimes generate structures that are appropriate for a different type of disc, a phenomenon termed transdetermination. Until recently, these phenomena were studied by physically fragmenting discs and then transplanting them into the abdomens of adult female flies. This field has experienced a renaissance following the development of genetic ablation systems that can damage precisely defined regions of the disc without the need for surgery. Together with more traditional approaches, these newer methods have generated many novel insights into wound healing, the mechanisms that drive regenerative growth, plasticity during regeneration and systemic effects of tissue damage and regeneration.

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“…Notably, intercellular calcium waves appear to be dependent on intracellular calcium mobilization [170,171]. Thus, intracellular calcium signaling is responsible for generating and propagating tissue scale calcium waves.…”

Section: Shared Regulators Of Cellular and Tissue-level Repairmentioning

confidence: 99%

Cellular mechanisms and signals that coordinate plasma membrane repair

Horn

Jaiswal

2018

Cell. Mol. Life Sci.

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Plasma membrane forms the barrier between the cytoplasm and the environment. Cells constantly and selectively transport molecules across their plasma membrane without disrupting it. Any disruption in the plasma membrane compromises its selective permeability and is lethal, if not rapidly repaired. There is a growing understanding of the organelles, proteins, lipids, and small molecules that help cells signal and efficiently coordinate plasma membrane repair. This review aims to summarize how these subcellular responses are coordinated and how cellular signals generated due to plasma membrane injury interact with each other to spatially and temporally coordinate repair. With the involvement of calcium and redox signaling in single cell and tissue repair, we will discuss how these and other related signals extend from single cell repair to tissue level repair. These signals link repair processes that are activated immediately after plasma membrane injury with longer term processes regulating repair and regeneration of the damaged tissue. We propose that investigating cell and tissue repair as part of a continuum of wound repair mechanisms would be of value in treating degenerative diseases.

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Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves

Cited by 51 publications

References 37 publications

Growth control in the Drosophila wing disk

Growth control in the Drosophila wing disk

Imaginal disc regeneration takes flight

Cellular mechanisms and signals that coordinate plasma membrane repair

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