The variability of temperature and precipitation influenced by El Niño-Southern Oscillation (ENSO) is potentially one of key factors contributing to vegetation product in southern Africa. Thus, understanding large-scale ocean-atmospheric phenomena like the ENSO and Indian Ocean Dipole/Dipole Mode Index (DMI) is important. In this study, 16 years (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017) of Moderate Resolution Imaging Spectroradiometer (MODIS) Terra/Aqua 16-day normalized difference vegetation index (NDVI), extracted and processed using JavaScript code editor in the Google Earth Engine (GEE) platform was used to analyze the vegetation response pattern of the oldest proclaimed nature reserve in Africa, the Hluhluwe-iMfolozi Park (HiP) to climatic variability. The MODIS enhanced vegetation index (EVI), burned area index (BAI), and normalized difference infrared index (NDII) were also analyzed. The study used the Modern Retrospective Analysis for the Research Application (MERRA) model monthly mean soil temperature and precipitations. The Global Land Data Assimilation System (GLDAS) evapotranspiration (ET) data were used to investigate the HiP vegetation water stress. The region in the southern part of the HiP which has land cover dominated by savanna experienced the most impact of the strong El Niño. Both the HiP NDVI inter-annual Mann-Kendal trend test and sequential Mann-Kendall (SQ-MK) test indicated a significant downward trend during the El Niño years of 2003 and 2014-2015. The SQ-MK significant trend turning point which was thought to be associated with the 2014-2015 El Niño periods begun in November 2012. The wavelet coherence and coherence phase indicated a positive teleconnection/correlation between soil temperatures, precipitation, soil moisture (NDII), and ET. This was explained by a dominant in-phase relationship between the NDVI and climatic parameters especially at a period band of 8-16 months. Climate 2018, 6, 95 2 of 24The influence of drought on vegetation varies in the spatial and temporal scales, and these are projected to increase with climate change [6,7]. This behavior affects wildlife, particularly in semi-arid and arid environments where herbivory is strongly restricted by vegetation extent and water availability [8]. In the north-east part of KwaZulu-Natal, South Africa, for example, droughts are becoming a recurrent and prominent feature [9,10], affecting vegetation, water and wildlife resources notably in the Hluhluwe-iMfolozi Park (HiP), the oldest proclaimed game reserve in Africa, as reported in this paper. Furthermore, these impacts have potential consequences that could incapacitate this game reserve's support of its specialist grazers such as rhinos [11].Understanding the association between vegetation productivity and climatic variables such as precipitation and temperature has, therefore, become a high priority. To address this, spatiotemporal tools that can integrate climate data with other information of interest are required....